Quinapril

62 interactions 1 explained in plain English
Also sold as: Accupril Accupril®
About Quinapril

Quinapril is an ACE inhibitor used to treat high blood pressure and heart failure. Read the full Quinapril drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Quinapril Aspirin Acuprin® Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Quinapril Aspirin Rectal Aspirin Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Quinapril Azathioprine Azasan Myelosuppression Details Quinapril Azilsartan Edarbi Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Quinapril Cyclosporine Injection Atopica Acute renal dysfunction and an increased risk of hyperkalemia Details Quinapril Cyclosporine Ophthalmic Cequa Acute renal dysfunction and an increased risk of hyperkalemia Details Quinapril Digoxin Cardoxin® An increased digoxin exposure Details Quinapril Eprosartan Teveten® Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Quinapril Everolimus Afinitor Increased risk of angioedema Details Quinapril Furosemide Injection Disal An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Quinapril Irbesartan Avapro Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Quinapril Lithium Carbonate Lithobid Increased risk of lithium toxicity Details Quinapril Losartan Arbli Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Quinapril Melphalan Alkeran An increased risk of severe hypotension Details Quinapril Melphalan Injection Alkeran An increased risk of severe hypotension Details Quinapril Mercaptopurine Purinethol® Myelosuppression Details

Moderate

Quinapril Acarbose Prandase® Explained An increased risk of hypoglycemia Details Quinapril Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Quinapril Alogliptin Nesina An increased risk of hypoglycemia Details Quinapril Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Quinapril Canagliflozin Invokana An increased risk of hypoglycemia Details Quinapril Capsaicin Arthricare for Women Moisturizing Increased risk of cough Details Quinapril Capsaicin Topical Aspercreme Warming® Increased risk of cough Details Quinapril Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased risk of cough Details Quinapril Dapagliflozin Farxiga An increased risk of hypoglycemia Details Quinapril Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Quinapril Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Quinapril Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Quinapril Diclofenac Transdermal Patch Flector Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Quinapril Dulaglutide Injection Trulicity An increased risk of hypoglycemia Details Quinapril Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hypoglycemia Details Quinapril Ertugliflozin Steglatro An increased risk of hypoglycemia Details Quinapril Etodolac Lodine Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Quinapril Exenatide Injection Bydureon An increased risk of hypoglycemia Details Quinapril Fenoprofen Fenopron Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Quinapril Flurbiprofen Ansaid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Quinapril Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Quinapril Glimepiride Amaryl An increased risk of hypoglycemia Details Quinapril Glipizide Glucotrol An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.