Raltegravir

14 interactions 2 explained in plain English
Also sold as: Isentress Isentress® Isentress® HD
About Raltegravir

Raltegravir is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults and children who weigh at least 4.5 lbs (2 kg). Raltegravir is in a class of medications called HIV integrase inhibitors. It works by decreasing the amount of HIV in the blood. Although raltegravir does not… Read the full Raltegravir drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Atogepant Azathioprine Cariprazine Amlodipine Cabotegravir Lumateperone
11 Major 3 Moderate
All (14) Major (11) Moderate (3)

Major

Raltegravir Atogepant Qulipta Reduced atogepant exposure Details Raltegravir Azathioprine Azasan An increased risk of hepatotoxicity Details Raltegravir Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Raltegravir Amlodipine Amvaz® Reduced amLODIPine exposure Details Raltegravir Cabotegravir Apretude Loss of virologic response and possible development of viral resistance Details Raltegravir Lumateperone Caplyta Reduced lumateperone exposure Details Raltegravir Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Raltegravir Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Raltegravir Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Raltegravir Nifedipine Adalat® Reduced NIFEdipine exposure Details Raltegravir Orlistat Alli Reduced efficacy of antiretrovirals, loss of virological control Details

Moderate

Raltegravir Omeprazole Gastrobim Explained Increased serum raltegravir concentrations Details Raltegravir Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Raltegravir Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details

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