Raltegravir

Name: Raltegravir Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

14 interactions 2 explained in plain English

Also sold as: Isentress Isentress® Isentress® HD

About Raltegravir

Raltegravir is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults and children who weigh at least 4.5 lbs (2 kg). Raltegravir is in a class of medications called HIV integrase inhibitors. It works by decreasing the amount of HIV in the blood. Although raltegravir does not… Read the full Raltegravir drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Atogepant Azathioprine Cariprazine Amlodipine Cabotegravir Lumateperone

11 Major 3 Moderate

All (14) Major (11) Moderate (3)

Moderate

Raltegravir Omeprazole Gastrobim Explained Increased serum raltegravir concentrations Details Raltegravir Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Raltegravir Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.