Relacorilant and Sertraline: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Relacorilant
Sertraline
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Here's what's going on. Relacorilant can slow down a liver enzyme (called CYP3A4) that helps break down many other medicines. Sertraline is partly handled by that same enzyme. When the two are taken together, sertraline may not clear out as quickly, so more of it can build up in your body. That can mean stronger side effects, like nausea, stomach upset, trouble sleeping, jitteriness, or dizziness.
The good news: this is something your care team can plan for. They may adjust your dose, keep a closer eye on how you feel, or choose a different option. Don't stop either medicine on your own. Just check in with your pharmacist or doctor so they can guide you.
Mechanism: Relacorilant inhibits CYP3A4, reducing metabolism of CYP3A4 substrates. Sertraline is a substrate (neither drug is a prodrug here), so combined use is expected to increase sertraline exposure (AUC/Cmax) and the risk of substrate-related adverse effects.
- Direction: increased sertraline effect/exposure
- Severity: major
- Evidence: probable
- Onset: unspecified
Management: Labeling advises avoiding concomitant use of relacorilant with CYP3A4 substrates unless otherwise recommended. If co-administration is necessary, individualize the substrate dose and monitor closely for serotonergic and other sertraline-related adverse effects (GI upset, insomnia, tremor, QT considerations).
What happens
Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions
Interaction Deep Dive
Unless there is a specific recommendation to do otherwise, relacorilant should not be given together with substrates of CYP3A4. When the two are used at the same time, exposure to the substrate may rise, along with a heightened risk of adverse reactions related to those substrates1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of relacorilant
How to manage this interaction
What your care team may do:
- Prefer to avoid using these two together unless there's a clear reason to combine them.
- If both are needed, your sertraline dose may be adjusted and individualized by your team.
- They may monitor you more closely for side effects like nausea, restlessness, sleep problems, or tremor.
What you should do:
- Keep taking both exactly as prescribed until your prescriber tells you otherwise.
- Tell your pharmacist or doctor you take both, and report any new or worsening side effects.
Management is individual — confirm any change with your pharmacist or prescriber.
Literature reports
1 report — tap to read
a) In drug interaction studies, giving relacorilant at 350 mg in the fasted state (1.8 times the relacorilant exposure achieved at the recommended dosage) once daily over 10 days together with midazolam (a CYP3A4 substrate) raised Cmax by 3.1-fold and AUC by 8.9-fold 1.
Common questions
Can I take Relacorilant and Sertraline together?
Relacorilant can raise sertraline levels and side effects by slowing its breakdown; this combo is generally avoided, so check with your pharmacist or doctor, who can adjust the dose or monitor you closely. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Relacorilant and Sertraline interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Relacorilant and Sertraline interaction managed?
What your care team may do: Prefer to avoid using these two together unless there's a clear reason to combine them. If both are needed, your sertraline dose may be adjusted and individualized by your team. They may monitor you more closely for side effects like nausea, restlessness, sleep problems, or tremor. What you should do: Keep taking both exactly as prescribed until your prescriber tells yo… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Relacorilant or Sertraline need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: LIFYORLI™ oral capsules, relacorilant oral capsules. Corcept Therapeutics Incorporated (Per Manufacturer), Redwood City, CA, 2026. DailyMed
Keep reading about Relacorilant
Keep reading about Sertraline
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist