Remimazolam

21 interactions 2 explained in plain English

Also sold as: Byfavo

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Midazolam Nasal Spray Lacosamide Injection Nalbuphine Injection Diphenhydramine Topical Butorphanol Injection Butorphanol Nasal Spray

20 Major 1 Moderate

All (21) Major (20) Moderate (1)

Major

Remimazolam Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Remimazolam Aripiprazole Injection Abilify Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Asenapine Transdermal Patch Secuado Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Butorphanol Injection Butorphic Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Butorphanol Nasal Spray Stadol® NS Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Diazepam Rectal Diastat Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Diphenhydramine Injection Banophen Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Diphenhydramine Topical Afterbite with Antihistamine Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Esketamine Nasal Spray Spravato Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Hydromorphone Injection Dilaudid Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Hydromorphone Rectal available generically Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Lacosamide Injection Motpoly An increased risk of CNS depression Details Remimazolam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Remimazolam Midazolam Nasal Spray Nayzilam Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Midazolam Injection Nayzilam Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, coma, and death Details Remimazolam Nalbuphine Injection Nubain® Increased risk of profound sedation, respiratory depression, coma, and death Details

Moderate

Remimazolam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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