Rifampin
176 interactions 12 explained in plain English
Also sold as:
Rifadin
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Rifampin Finerenone Kerendia Reduced finerenone exposure and reduced efficacy of finerenone Details Rifampin Fostamatinib Tavalisse Reduced exposure to the active metabolite Details Rifampin Futibatinib Lytgobi Reduced futibatinib exposure and reduced efficacy Details Rifampin Gefitinib Iressa Decreased exposure of gefitinib Details Rifampin Gilteritinib Xospata Reduced gilteritinib exposure Details Rifampin Glasdegib Daurismo Decreased glasdegib exposure Details Rifampin Glipizide Glucotrol Reduced glipiZIDE exposure Details Rifampin Hydroxychloroquine Plaquenil Decreased efficacy of hydroxychloroquine Details Rifampin Ibrexafungerp Brexafemme Decreased ibrexafungerp plasma concentrations Details Rifampin Ibrutinib Imbruvica Decreased ibrutinib exposure Details Rifampin Ifosfamide Injection Ifex Increased neurotoxic and nephrotoxic effects Details Rifampin Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Rifampin Irinotecan Camptosar Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Rifampin Irinotecan Injection Camptosar Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Rifampin Irinotecan Lipid Complex Injection Onivyde® Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Rifampin Istradefylline Nourianz Decreased istradefylline exposure Details Rifampin Ivabradine Corlanor Decreased exposure of ivabradine Details Rifampin Ixabepilone Injection IXEMPRA Decreased ixabepilone exposure and efficacy Details Rifampin Ixazomib Ninlaro Decreased ixazomib exposure Details Rifampin Ketoconazole Topical Extina® Foam Reduced ketoconazole exposure and reduce efficacy of ketoconazole Details Rifampin Lefamulin Xenleta Altered (increased/reduced) lefamulin exposure, reduced efficacy of lefamulin and an increased risk of lefamulin-related adverse r... Details Rifampin Leniolisib Joenja Reduced leniolisib exposure and reduced efficacy of leniolisib Details Rifampin Letermovir Injection Prevymis Altered letermovir exposure and reduced efficacy of letermovir Details Rifampin Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Rifampin Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Rifampin Linagliptin Tradjenta Reduced linagliptin exposure Details Rifampin Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Rifampin Losartan Arbli Reduced losartan exposure and reduced losartan active metabolite exposure Details Rifampin Lumateperone Caplyta Reduced lumateperone exposure Details Rifampin Lurbinectedin Injection Zepzelca Reduced lurbinectedin exposure and reduced efficacy of lurbinectedin Details Rifampin Macitentan Opsumit Reduced macitentan exposure Details Rifampin Maraviroc Selzentry Reduced maraviroc exposure Details Rifampin Medroxyprogesterone Amen® Reduced medroxyPROGESTERone exposure Details Rifampin Medroxyprogesterone Injection Depo-Provera Reduced medroxyPROGESTERone exposure Details Rifampin Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Rifampin Methylergonovine Methergine Reduced methylergonovine exposure and reduced efficacy of methylergonovine Details Rifampin Mexiletine Mexitil® Reduced mexiletine exposure Details Rifampin Midostaurin Rydapt Decreased midostaurin exposure Details Rifampin Mitapivat Aqvesme Reduced mitapivat exposure and reduced efficacy of mitapivat Details Rifampin Morphine Injection Astramorph® PF Increased or reduced morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depress... DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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