Rifampin
176 interactions 12 explained in plain English
Also sold as:
Rifadin
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Rifampin Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Rifampin Omeprazole Gastrobim Explained Reduced omeprazole exposure Details Rifampin Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Rifampin Relugolix Orgovyx Explained Altered relugolix exposure, an increased risk of relugolix-related adverse reactions and reduced efficacy of relugolix Details Rifampin Simvastatin Flolipid Explained Reduced simvastatin exposure and reduced efficacy of simvastatin Details Rifampin Abemaciclib Verzenio Explained Decreased abemaciclib plasma concentration Details Rifampin Abrocitinib Cibinqo Explained Decreased abrocitinib and active metabolite exposure Details Rifampin Acalabrutinib Calquence Reduced acalabrutinib exposure Details Rifampin Alpelisib Piqray Reduced alpelisib exposure and reduced efficacy of alpelisib Details Rifampin Apixaban Eliquis Explained Reduced apixaban exposure, reduced efficacy of apixaban and an increased risk of stroke and other thromboembolic events Details Rifampin Apremilast Otezla Reduced apremilast exposure and an reduced efficacy of apremilast Details Rifampin Aripiprazole Injection Abilify Reduced ARIPiprazole exposure Details Rifampin Asciminib Scemblix Reduced asciminib exposure and reduced efficacy of asciminib Details Rifampin Atogepant Qulipta Altered atogepant exposure Details Rifampin Atovaquone Mepron Reduced atovaquone exposure, an increased rifAMPin exposure and an increased risk of rifAMPin-related adverse reactions Details Rifampin Avapritinib Ayvakit Reduced avapritinib exposure and reduced efficacy of avapritinib Details Rifampin Avatrombopag Doptelet Decreased avatrombopag exposure Details Rifampin Azathioprine Azasan An increased risk of hepatotoxicity Details Rifampin Belumosudil Rezurock Explained Reduced belumosudil exposure and reduced efficacy of belumosudil Details Rifampin Betrixaban Bevyxxa® Decreased betrixaban exposure Details Rifampin Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Rifampin Abiraterone Abirtega Reduced abiraterone exposure and reduced efficacy of abiraterone Details Rifampin Afatinib Gilotrif Decreased afatinib exposure Details Rifampin Amlodipine Amvaz® Reduced amLODIPine exposure Details Rifampin Axitinib Inlyta Reduced axitinib exposure Details Rifampin Bedaquiline Sirturo Reduced bedaquiline exposure and reduced efficacy of bedaquiline Details Rifampin Bendamustine Injection Belrapzo Reduced bendamustine exposure and reduced efficacy of bendamustine Details Rifampin Bortezomib Boruzu Reduced bortezomib exposure Details Rifampin Bosutinib Bosulif Reduced bosutinib exposure and reduced efficacy of bosutinib Details Rifampin Brexpiprazole Rexulti Reduced brexpiprazole exposure Details Rifampin Brigatinib Alunbrig Reduced brigatinib efficacy Details Rifampin Brivaracetam Briviact Decreased brivaracetam plasma concentrations Details Rifampin Brivaracetam Injection Briviact Decreased brivaracetam plasma concentrations Details Rifampin Busulfan Injection Busulfex Reduced busulfan exposure Details Rifampin Cabozantinib Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Rifampin Cabozantinib (Thyroid Cancer) Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Rifampin Capmatinib Tabrecta Decreased capmatinib exposure and reduction of antitumor activity Details Rifampin Cefazolin Increased or prolonged prothrombin time and an increased risk of bleeding Details Rifampin Cefazolin Injection Ancef® Increased or prolonged prothrombin time and an increased risk of bleeding Details Rifampin Chloramphenicol Injection Chloromycetin® Injection Reduced chloramphenicol exposure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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