Rifampin

Name: Rifampin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

176 interactions 12 explained in plain English

Also sold as: Rifadin

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fostemsavir Cabotegravir Aficamten Doravirine Nifedipine Lurasidone

9 Contraindicated 130 Major 34 Moderate 3 Minor

All (176) Contraindicated (9) Major (130) Moderate (34) Minor (3)

Major

Rifampin Moxifloxacin Avelox Reduced moxifloxacin exposure Details Rifampin Moxifloxacin Injection Avelox Reduced moxifloxacin exposure Details Rifampin Moxifloxacin Ophthalmic Moxeza® Reduced moxifloxacin exposure Details Rifampin Naloxegol Movantik Reduced naloxegol exposure and reduced efficacy of naloxegol Details Rifampin Neratinib Nerlynx Decreased exposure of neratinib and active metabolites and risk of reduced efficacy Details Rifampin Nevirapine Viramune Reduced nevirapine exposure and reduced efficacy of nevirapine Details Rifampin Nimodipine Nimotop Reduced nimodipine plasma concentrations and reduced nimodipine efficacy Details Rifampin Nintedanib Ofev Reduced nintedanib exposure Details Rifampin Olaparib Lynparza Decreased olaparib exposure and efficacy Details Rifampin Olutasidenib Rezlidhia Reduced olutasidenib exposure Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.