Drug Interaction Report

Rilpivirine and Dolasetron Injection: Interaction Details

A pharmacist-reviewed analysis of the Rilpivirine and Dolasetron Injection interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Dolasetron Injection

Anzemet Anzemet® Injection
+

Rilpivirine

Edurant Edurant® Juluca® (as a combination product containing dolutegravir, rilpivirine)
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 73 documented Rilpivirine interactions, 65 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

An increased risk of QT interval prolongation and torsade de pointes

Interaction Deep Dive

Concomitant use of rilpivirine and a QT interval prolonging drug may lead to an increased risk of QT interval prolongation and torsade de pointes. Consider alternatives to rilpivirine when coadministered with a drug with a known risk of torsade de pointes12.

Why it happens (mechanism)

Additive QT interval prolongation

Common questions

Can I take Rilpivirine and Dolasetron Injection together?

An increased risk of QT interval prolongation and torsade de pointes Always confirm with your pharmacist or prescriber before making any change.

How serious is the Rilpivirine and Dolasetron Injection interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Rilpivirine or Dolasetron Injection need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (2)

  1. Product Information: EDURANT(R) PED oral tablets for suspension, rilpivirine oral tablets for suspension. Janssen Therapeutics (per FDA), Horsham, Pa, 2024. DailyMed
  2. Product Information: EDURANT(R) oral tablets, rilpivirine oral tablets. Janssen Therapeutics (per FDA), Horsham, Pa, 2024. DailyMed
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Dolasetron Injection

Keep reading about Dolasetron Injection

All Dolasetron Injection interactions (296) Dolasetron Injection drug information
Also serious with: Levoketoconazole Levomethadyl Mesoridazine Phenelzine
Rilpivirine

Keep reading about Rilpivirine

All Rilpivirine interactions (73) Rilpivirine drug information
Also serious with: Dexlansoprazole Omeprazole Ketoconazole Topical Esomeprazole
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Rilpivirine + Activated Charcoal American Hellebore Arsenic Beer Cesium Ephedra Grapefruit Siberian Cocklebur + 167 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.