Rilpivirine
73 interactions 6 explained in plain English
Also sold as:
Edurant
Edurant®
Juluca® (as a combination product containing dolutegravir, rilpivirine)
About Rilpivirine
Rilpivirine is used along with other medications to treat human immunodeficiency virus type 1 (HIV-1) in certain adults and children 12 years of age and older who weigh at least 77 lb (35 kg) and have not received antiretroviral treatment in the past. It is also used along with cabotegravir (Vocabria) as a short-term t… Read the full Rilpivirine drug information page →
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jun 30, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Dexamethasone Ophthalmic
Omeprazole
Esomeprazole
Dexamethasone Injection
Dexlansoprazole
Ketoconazole Topical
Contraindicated
Rilpivirine Omeprazole Gastrobim Explained Reduced oral rilpivirine exposure, reduced efficacy of rilpivirine and an increased loss of virologic response Details Rilpivirine Dexamethasone Injection Decadron Reduced rilpivirine exposure, reduced efficacy of rilpivirine and an increased risk of loss of virologic response Details Rilpivirine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced rilpivirine exposure, reduced efficacy of rilpivirine and an increased risk of loss of virologic response Details Rilpivirine Dexlansoprazole Dexilant Reduced oral rilpivirine exposure, reduced efficacy of rilpivirine and an increased loss of virologic response Details Rilpivirine Esomeprazole Nexium Reduced oral rilpivirine exposure, reduced efficacy of rilpivirine and an increased loss of virologic response Details Rilpivirine Esomeprazole Injection Nexium Reduced oral rilpivirine exposure, reduced efficacy of rilpivirine and an increased loss of virologic response Details Rilpivirine Ketoconazole Topical Extina® Foam Increased rilpivirine exposure, increased risk of fungal infection and an increased risk of QT interval prolongation Details Rilpivirine Lansoprazole Prevacid Reduced oral rilpivirine exposure, reduced efficacy of rilpivirine and an increased loss of virologic response DetailsMajor
Rilpivirine Abametapir Explained Increased exposure of CYP3A4 substrate Details Rilpivirine Amitriptyline Elavil Explained An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Sertraline Explained An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Rilpivirine Amisulpride Injection Barhemsys An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Rilpivirine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Rilpivirine Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Rilpivirine Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Azithromycin AzaSite Increased rilpivirine exposure and an increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Alfuzosin UroXatral An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Anagrelide Agrylin Increased risk of QT interval prolongation Details Rilpivirine Bedaquiline Sirturo An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Chloroquine Aralen® An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Dasatinib Phyrago An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Rilpivirine Deutetrabenazine Austedo An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Disopyramide Norpace An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Dofetilide Tikosyn An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Dolasetron Anzemet An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Dolasetron Injection Anzemet An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Encorafenib Braftovi An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Entrectinib Rozlytrek An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Eribulin Injection Halaven An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Famotidine Calmicid Reduced rilpivirine exposure and an increased risk of QT interval prolongation Details Rilpivirine Famotidine Injection Calmicid Reduced rilpivirine exposure and an increased risk of QT interval prolongation Details Rilpivirine Felbamate Felbatol An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Flecainide Tambocor® An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Foscarnet Injection Foscavir An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Galantamine Razadyne An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation and torsade de pointes DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacistEducational information only, not medical advice. Always confirm interactions with your pharmacist
or prescriber before making any change to your medications.