Rilpivirine

73 interactions 6 explained in plain English

Also sold as: Edurant Edurant® Juluca® (as a combination product containing dolutegravir, rilpivirine)

About Rilpivirine

Rilpivirine is used along with other medications to treat human immunodeficiency virus type 1 (HIV-1) in certain adults and children 12 years of age and older who weigh at least 77 lb (35 kg) and have not received antiretroviral treatment in the past. It is also used along with cabotegravir (Vocabria) as a short-term t… Read the full Rilpivirine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dexamethasone Ophthalmic Omeprazole Esomeprazole Dexamethasone Injection Dexlansoprazole Ketoconazole Topical

8 Contraindicated 65 Major

All (73) Contraindicated (8) Major (65)

Major

Rilpivirine Gemifloxacin Factive An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Glasdegib Daurismo An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Rilpivirine Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Granisetron Injection Granisol An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Rilpivirine Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Rilpivirine Inotuzumab Ozogamicin Injection Besponsa An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Ivabradine Corlanor An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Lefamulin Xenleta An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Lenvatinib Lenvima An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Rilpivirine Levofloxacin Levaquin Increased risk of QT interval prolongation Details Rilpivirine Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Rilpivirine Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Rilpivirine Mefloquine Lariam® An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Metronidazole Flagyl An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Metronidazole Injection Flagyl An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Moxifloxacin Avelox Increased risk of QT interval prolongation Details Rilpivirine Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Rilpivirine Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Rilpivirine Nevirapine Viramune Reduced rilpivirine exposure and altered nevirapine exposure Details Rilpivirine Nizatidine Axid® Reduced rilpivirine exposure Details Rilpivirine Octreotide Bynfezia An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Octreotide Injection Bynfezia An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Ofloxacin Floxin® An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Rilpivirine Oxaliplatin Injection Eloxatin® An increased risk of QT interval prolongation and torsade de pointes Details Rilpivirine Orlistat Alli Reduced efficacy of antiretrovirals, loss of virological control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.