Ripretinib

Name: Ripretinib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

5 interactions 1 explained in plain English

Also sold as: Qinlock Qinlock®

About Ripretinib

Ripretinib is used to treat gastrointestinal stromal tumors (GIST; a type of tumor that grows in the stomach, intestine [bowel], or esophagus [tube that connects the throat with the stomach]) in adults who have previously received other medications, including imatinib (Gleevec). Ripretinib is in a class of medications… Read the full Ripretinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abametapir Letermovir Injection Nafcillin Injection

3 Major 2 Moderate

All (5) Major (3) Moderate (2)

Major

Ripretinib Abametapir Explained Increased exposure of CYP3A4 substrate Details Ripretinib Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Ripretinib Nafcillin Injection Unipen® Injection Decreased exposure of ripretinib and its active metabolite and reduction of antitumor activity Details

Moderate

Ripretinib Ketoconazole Topical Extina® Foam Increased exposure of ripretinib and its active metabolite and increased risk of adverse reactions Details Ripretinib Levothyroxine Ermeza Increased risk of hypothyroidism Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.