Rivaroxaban

75 interactions 3 explained in plain English
Also sold as: Xarelto Xarelto®
About Rivaroxaban

Rivaroxaban is a blood thinner that treats and prevents blood clots in the legs, lungs, and other areas. Read the full Rivaroxaban drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Orlistat Enoxaparin Injection Nintedanib Aspirin Edoxaban
1 Contraindicated 68 Major 6 Moderate
All (75) Contraindicated (1) Major (68) Moderate (6)

Major

Rivaroxaban Ketoprofen Actron® An increased risk of bleeding Details Rivaroxaban Ketorolac Acular An increased risk of bleeding Details Rivaroxaban Ketorolac Injection Acular An increased risk of bleeding Details Rivaroxaban Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Rivaroxaban Ketorolac Ophthalmic Acular An increased risk of bleeding Details Rivaroxaban Lecanemab-Irmb Injection Leqembi An increased risk of amyloid related imaging abnormalities (ARIA), or intracerebral hemorrhage Details Rivaroxaban Lenacapavir Injection Sunlenca Increased rivaroxaban exposure and an increased risk of rivaroxaban-related adverse reactions Details Rivaroxaban Lenacapavir Oral Sunlenca Increased rivaroxaban exposure and an increased risk of rivaroxaban-related adverse reactions Details Rivaroxaban Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Rivaroxaban Levetiracetam Elepsia Decreased rivaroxaban exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Rivaroxaban Levetiracetam Injection Elepsia Decreased rivaroxaban exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Rivaroxaban Meclofenamate Meclodium® An increased risk of bleeding Details Rivaroxaban Mefenamic Acid Ponstel® An increased risk of bleeding Details Rivaroxaban Meloxicam Alloxate An increased risk of bleeding Details Rivaroxaban Meloxicam Injection Alloxate An increased risk of bleeding Details Rivaroxaban Melphalan Alkeran An increased risk of bleeding Details Rivaroxaban Melphalan Injection Alkeran An increased risk of bleeding Details Rivaroxaban Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Rivaroxaban Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Rivaroxaban Minocycline Amzeeq An increased risk of bleeding Details Rivaroxaban Minocycline Topical Amzeeq An increased risk of bleeding Details Rivaroxaban Nabumetone Relafen An increased risk of bleeding Details Rivaroxaban Naproxen Aleve An increased risk of bleeding Details Rivaroxaban Nevirapine Viramune Reduced plasma concentrations of rivaroxaban Details Rivaroxaban Nintedanib Ofev Increased risk of bleeding Details Rivaroxaban Omadacycline Nuzyra Increased risk of bleeding Details Rivaroxaban Omadacycline Injection Nuzyra Increased risk of bleeding Details Rivaroxaban Oxaliplatin Injection Eloxatin® Increased risk of bleeding Details Rivaroxaban Orlistat Alli An increased risk of bleeding Details

Moderate

Rivaroxaban Dexamethasone Injection Decadron Increased risk of gastrointestinal bleeding Details Rivaroxaban Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal bleeding Details Rivaroxaban Hydrocortisone Ala-Cort Increased risk of gastrointestinal bleeding Details Rivaroxaban Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal bleeding Details Rivaroxaban Icosapent Ethyl Vascepa An increased risk of bleeding Details Rivaroxaban Levothyroxine Ermeza Increased response to oral anticoagulant therapy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.