Rivaroxaban

Name: Rivaroxaban Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

75 interactions 3 explained in plain English

Also sold as: Xarelto Xarelto®

About Rivaroxaban

Rivaroxaban is a blood thinner that treats and prevents blood clots in the legs, lungs, and other areas. Read the full Rivaroxaban drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Orlistat Enoxaparin Injection Nintedanib Aspirin Edoxaban

1 Contraindicated 68 Major 6 Moderate

All (75) Contraindicated (1) Major (68) Moderate (6)

Moderate

Rivaroxaban Dexamethasone Injection Decadron Increased risk of gastrointestinal bleeding Details Rivaroxaban Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal bleeding Details Rivaroxaban Hydrocortisone Ala-Cort Increased risk of gastrointestinal bleeding Details Rivaroxaban Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal bleeding Details Rivaroxaban Icosapent Ethyl Vascepa An increased risk of bleeding Details Rivaroxaban Levothyroxine Ermeza Increased response to oral anticoagulant therapy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.