Samidorphan
12 interactions 2 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Acetaminophen And Codeine
Buprenorphine
Butorphanol Injection
Butorphanol Nasal Spray
Fentanyl Transdermal Patch
Hydromorphone Injection
Contraindicated
Samidorphan Acetaminophen And Codeine Capital® & Codeine Explained Decreased opioid efficacy and precipitation of opioid withdrawal Details Samidorphan Buprenorphine Belbuca Explained Decreased opioid efficacy and precipitation of opioid withdrawal Details Samidorphan Butorphanol Injection Butorphic Decreased opioid efficacy and precipitation of opioid withdrawal Details Samidorphan Butorphanol Nasal Spray Stadol® NS Decreased opioid efficacy and precipitation of opioid withdrawal Details Samidorphan Fentanyl Transdermal Patch Duragesic® Decreased opioid efficacy and precipitation of opioid withdrawal Details Samidorphan Hydromorphone Injection Dilaudid Decreased opioid efficacy and precipitation of opioid withdrawal Details Samidorphan Hydromorphone Rectal available generically Decreased opioid efficacy and precipitation of opioid withdrawal Details Samidorphan Morphine Injection Astramorph® PF Decreased opioid efficacy and precipitation of opioid withdrawal Details Samidorphan Nalbuphine Injection Nubain® Decreased opioid efficacy and precipitation of opioid withdrawal DetailsMajor
Samidorphan Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Samidorphan Naldemedine Symproic Increased risk of opioid withdrawal Details Samidorphan Naloxegol Movantik Risk of opioid withdrawal DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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