Sapropterin

Name: Sapropterin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

4 interactions

Also sold as: Javygtor Kuvan Kuvan® Zelvysia

About Sapropterin

Sapropterin is used along with a restricted diet to control blood phenylalanine levels in adults and children 1 month of age and older who have phenylketonuria (PKU; an inborn condition in which phenylalanine may build up in the blood and causes decreased intelligence and a decreased ability to focus, remember, and org… Read the full Sapropterin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levodopa Oral Inhalation Methotrexate Methotrexate Injection Pemetrexed Injection

4 Major

All (4) Major (4)

Major

Sapropterin Levodopa Oral Inhalation Inbrija Increased risk of neurologic disorders Details Sapropterin Methotrexate Jylamvo Decreased tetrahydrobiopterin (BH4) levels and increased phenylalanine levels Details Sapropterin Methotrexate Injection Abitrexate® Decreased tetrahydrobiopterin (BH4) levels and increased phenylalanine levels Details Sapropterin Pemetrexed Injection Alimta Decreased tetrahydrobiopterin (BH4) levels and increased phenylalanine levels Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.