Sarecycline

Name: Sarecycline Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

38 interactions 4 explained in plain English

Also sold as: Seysara Seysara®

About Sarecycline

Sarecycline is used to treat certain types of acne in adults and children 9 years of age and older. Sarecycline is in a class of medications called tetracycline antibiotics. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne. Antibiotics su… Read the full Sarecycline drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Acitretin Cyclosporine Injection Isotretinoin Enoxaparin Injection Penicillin V Potassium

2 Contraindicated 34 Major 2 Moderate

All (38) Contraindicated (2) Major (34) Moderate (2)

Contraindicated

Sarecycline Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Sarecycline Acitretin Soriatane® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.