Sarecycline

38 interactions 4 explained in plain English
Also sold as: Seysara Seysara®
About Sarecycline

Sarecycline is used to treat certain types of acne in adults and children 9 years of age and older. Sarecycline is in a class of medications called tetracycline antibiotics. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne. Antibiotics su… Read the full Sarecycline drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Sarecycline Relugolix Orgovyx Explained Increased relugolix exposure Details Sarecycline Isotretinoin Absorica Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Sarecycline Amoxicillin Amoxi Drop Decreased antibacterial effectiveness Details Sarecycline Ampicillin Amcill® Decreased antibacterial effectiveness Details Sarecycline Ampicillin Injection Omnipen-N® Decreased antibacterial effectiveness Details Sarecycline Apixaban Eliquis Explained Increased risk of bleeding Details Sarecycline Betrixaban Bevyxxa® Increased risk of bleeding Details Sarecycline Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Sarecycline Bexarotene Topical Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Sarecycline Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Sarecycline Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Sarecycline Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Sarecycline Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Sarecycline Dalteparin Injection Fragmin Increased risk of bleeding Details Sarecycline Digoxin Cardoxin® Increased digoxin exposure Details Sarecycline Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Sarecycline Edoxaban Savaysa Increased risk of bleeding Details Sarecycline Enoxaparin Lovenox Increased risk of bleeding Details Sarecycline Enoxaparin Injection Lovenox Increased risk of bleeding Details Sarecycline Fondaparinux Arixtra Increased risk of bleeding Details Sarecycline Fondaparinux Injection Arixtra Increased risk of bleeding Details Sarecycline Heparin Increased risk of bleeding Details Sarecycline Heparin Injection Lipo-Hepin® Increased risk of bleeding Details Sarecycline Lefamulin Xenleta Increased lefamulin exposure and an increased risk of lefamulin-related adverse reactions Details Sarecycline Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Sarecycline Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Sarecycline Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Sarecycline Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Sarecycline Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Sarecycline Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Sarecycline Nafcillin Injection Unipen® Injection Decreased antibacterial effectiveness Details Sarecycline Penicillin G Benzathine Injection Bicillin Decreased antibacterial effectiveness Details Sarecycline Penicillin G Procaine Injection Bactracillin G Decreased antibacterial effectiveness Details Sarecycline Penicillin V Potassium Beepen-VK® Decreased antibacterial effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.