Selegiline

48 interactions 6 explained in plain English
Also sold as: Anipryl Zelapar
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amitriptyline Methyldopa Deutetrabenazine Morphine Injection Methylphenidate Maprotiline
11 Contraindicated 19 Major 18 Moderate
All (48) Contraindicated (11) Major (19) Moderate (18)

Moderate

Selegiline Acarbose Prandase® Explained An increased risk of hypoglycemia Details Selegiline Dexamethasone Injection Decadron Reduced selegiline exposure Details Selegiline Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced selegiline exposure Details Selegiline Dopamine Increased hypertensive effects Details Selegiline Estradiol Delestrogen An increase in selegiline oral bioavailability and an increased risk of selegiline adverse reactions Details Selegiline Estradiol Topical Divigel An increase in selegiline oral bioavailability and an increased risk of selegiline adverse reactions Details Selegiline Estradiol Transdermal Patch Alora® An increase in selegiline oral bioavailability and an increased risk of selegiline adverse reactions Details Selegiline Glimepiride Amaryl An increased risk of hypoglycemia Details Selegiline Glipizide Glucotrol An increased risk of hypoglycemia Details Selegiline Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Selegiline Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Selegiline Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Selegiline Levonorgestrel After banger An increase in selegiline oral bioavailability and an increased risk of selegiline adverse reactions Details Selegiline Levonorgestrel Intrauterine System Kyleena An increase in selegiline oral bioavailability and an increased risk of selegiline adverse reactions Details Selegiline Metformin Fortamet® An increased risk of hypoglycemia Details Selegiline Nafcillin Injection Unipen® Injection Reduced selegiline exposure Details Selegiline Nateglinide Starlix® An increased risk of hypoglycemia Details Selegiline Nevirapine Viramune Reduced selegiline exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.