Selpercatinib

103 interactions 8 explained in plain English
Also sold as: Retevmo Retevmo®
About Selpercatinib

Selpercatinib is used to treat a certain type of non-small cell lung cancer (NSCLC) in adults that has spread to nearby tissues or other parts of the body. It is also used to treat a certain type of thyroid cancer in adults and children 12 years of age and older that has spread to other parts of the body. Selpercatinib… Read the full Selpercatinib drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Oxaliplatin Injection Axitinib Felbamate Eribulin Injection Levofloxacin Injection
1 Contraindicated 99 Major 3 Moderate
All (103) Contraindicated (1) Major (99) Moderate (3)

Major

Selpercatinib Metronidazole Vaginal MetroGel® Vaginal Increased risk of QT interval prolongation Details Selpercatinib Midostaurin Rydapt Increased substrate exposure and an increased risk for adverse effects Details Selpercatinib Mitapivat Aqvesme Reduced selpercatinib exposure and reduced anti-tumor activity Details Selpercatinib Moxifloxacin Avelox Increased risk of QT interval prolongation Details Selpercatinib Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Selpercatinib Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Selpercatinib Nafarelin Nasal Spray Synarel Increased risk of QT interval prolongation Details Selpercatinib Nafcillin Injection Unipen® Injection Reduced selpercatinib exposure and reduced anti-tumor activity Details Selpercatinib Neratinib Nerlynx Increased substrate exposure and an increased risk for adverse effects Details Selpercatinib Nifedipine Adalat® Increased NIFEdipine exposure Details Selpercatinib Nizatidine Axid® Reduced selpercatinib exposure and reduced anti-tumor activity Details Selpercatinib Octreotide Bynfezia Increased risk of QT interval prolongation Details Selpercatinib Octreotide Injection Bynfezia Increased risk of QT interval prolongation Details Selpercatinib Ofloxacin Floxin® Increased risk of QT interval prolongation Details Selpercatinib Ofloxacin Ophthalmic Ocuflox Increased risk of QT interval prolongation Details Selpercatinib Ofloxacin Otic Floxin® Otic Increased risk of QT interval prolongation Details Selpercatinib Olaparib Lynparza Increased substrate exposure and an increased risk for adverse effects Details Selpercatinib Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Selpercatinib Oxaliplatin Injection Eloxatin® Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.