Selpercatinib

Name: Selpercatinib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

103 interactions 8 explained in plain English

Also sold as: Retevmo Retevmo®

About Selpercatinib

Selpercatinib is used to treat a certain type of non-small cell lung cancer (NSCLC) in adults that has spread to nearby tissues or other parts of the body. It is also used to treat a certain type of thyroid cancer in adults and children 12 years of age and older that has spread to other parts of the body. Selpercatinib… Read the full Selpercatinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Oxaliplatin Injection Axitinib Felbamate Eribulin Injection Levofloxacin Injection

1 Contraindicated 99 Major 3 Moderate

All (103) Contraindicated (1) Major (99) Moderate (3)

Contraindicated

Selpercatinib Ketoconazole Topical Extina® Foam Increased selpercatinib exposure and an increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.