Sepiapterin

Name: Sepiapterin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

5 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Avanafil Levodopa Oral Inhalation Methotrexate Methotrexate Injection Pemetrexed Injection

5 Major

All (5) Major (5)

Major

Sepiapterin Avanafil Stendra An increased risk of hypotension Details Sepiapterin Levodopa Oral Inhalation Inbrija An increased risk of seizures Details Sepiapterin Methotrexate Jylamvo Reduced sepiapterin metabolism to tetrahydrobiopterin Details Sepiapterin Methotrexate Injection Abitrexate® Reduced sepiapterin metabolism to tetrahydrobiopterin Details Sepiapterin Pemetrexed Injection Alimta Reduced sepiapterin metabolism to tetrahydrobiopterin Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.