Sertraline and Bromopride: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Bromopride
No brand names on recordSertraline
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Bromopride is a medicine that helps with nausea and stomach problems, and sertraline is a common antidepressant. Both can affect the brain's movement signals, and using them together may raise the chance of a side effect called an extrapyramidal reaction. That's a fancy term for things like muscle stiffness, restlessness, tremors, or unusual movements you can't control.
Because of this, these two are generally not recommended together. The good news is your care team can manage this. Please don't stop either medicine on your own. Instead, talk with your pharmacist or doctor so they can review your options and keep you safe.
Interaction: Additive risk of extrapyramidal symptoms (EPS) when bromopride is combined with sertraline.
- Mechanism: Additive/pharmacodynamic. Bromopride is a central dopamine (D2) antagonist that can cause EPS; SSRIs including sertraline can contribute to EPS through serotonergic modulation of dopaminergic pathways. Neither drug is a prodrug relevant to this effect.
- Direction: Increased EPS risk (dystonia, akathisia, parkinsonism, potentially tardive dyskinesia).
- Onset: Unspecified.
- Evidence: Theoretical.
- Severity on file: Contraindicated.
- Management: Avoid concomitant use; if unavoidable, monitor closely for movement disorders and reassess therapy.
What happens
Increased risk of extrapyramidal reactions
Interaction Deep Dive
The combined administration of bromopride together with additional agents capable of producing extrapyramidal reactions is contraindicated1.
Why it happens (mechanism)
Additive extrapyramidal side effects
How to manage this interaction
The record lists this combination as one to avoid, so your care team will decide the safest plan for you.
- Keep taking both medicines as prescribed until you have spoken with your prescriber or pharmacist. Do not stop either one on your own.
- Your team may choose an alternative to one of these medicines, or monitor you more closely for movement-related side effects if both are needed.
- Report any muscle stiffness, tremor, restlessness, unusual movements, or difficulty moving promptly.
Bring this up at your next contact with your pharmacist or doctor so the plan can be tailored to you.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Sertraline and Bromopride together?
Using bromopride with sertraline may raise the risk of movement-related side effects and is flagged as a combination to avoid; keep taking both as prescribed and talk with your pharmacist or doctor about the safest option. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Sertraline and Bromopride interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Sertraline and Bromopride interaction managed?
The record lists this combination as one to avoid, so your care team will decide the safest plan for you. Keep taking both medicines as prescribed until you have spoken with your prescriber or pharmacist. Do not stop either one on your own. Your team may choose an alternative to one of these medicines, or monitor you more closely for movement-related side effects if both are needed. Report any mus… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Sertraline or Bromopride need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: DIGESAN(R) oral capsules, bromopride oral capsules. Sanofi-Aventis Farmaceutica Ltda (per Anvisa), Suzano, Brazil, 2014.
Keep reading about Bromopride
Keep reading about Sertraline
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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