Sertraline and Delamanid: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Sertraline
No brand names on recordDelamanid
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Both of these medicines can affect your heart's rhythm. Sertraline (an antidepressant) and delamanid (a medicine for tuberculosis) can each slightly stretch out a part of your heartbeat called the QT interval. When you take them together, that effect can add up, which can raise the risk of an irregular heartbeat.
This is a theoretical concern based on how the drugs work, not a common event, but it is taken seriously because heart rhythm problems can be dangerous. The good news is your care team can manage this. Please don't stop either medicine on your own, just talk with your doctor or pharmacist so they can decide the safest plan for you.
Mechanism: Additive QT-interval prolongation. Both sertraline and delamanid are independently associated with QTc prolongation; concurrent use produces a pharmacodynamic additive effect increasing risk of ventricular arrhythmias, including torsades de pointes. Neither is a prodrug and the interaction is PD, not PK.
- Direction: Additive QT effect (increased arrhythmia risk).
- Evidence: Theoretical.
- Severity: Major. Onset unspecified.
- Management: Documented guidance is to avoid coadministration. If unavoidable, obtain baseline and follow-up ECGs, monitor and correct electrolytes (K+, Mg2+), and review other QT-prolonging agents.
What happens
An increased risk of QT interval prolongation
Interaction Deep Dive
Do not administer sertraline together with this drug, since combining them can elevate the likelihood of QT prolongation and/or ventricular arrhythmias1.
Why it happens (mechanism)
Additive QT interval prolongation
How to manage this interaction
What your care team may do:
- Because the guidance on file is to avoid using these two together, your prescriber may consider an alternative to one of them.
- If both are needed, they may monitor you more closely, including checking your heart rhythm (ECG) and your blood levels of potassium and magnesium.
What you can do:
- Keep taking both exactly as prescribed unless your doctor tells you otherwise.
- Tell your pharmacist or prescriber you are on both drugs, and mention any fainting, dizziness, or a fluttering or pounding heartbeat right away.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Sertraline and Delamanid together?
Combining sertraline and delamanid can add up their effects on heart rhythm, so the guidance is to avoid using them together. Don't change anything on your own; let your doctor or pharmacist choose the safest plan. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Sertraline and Delamanid interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Sertraline and Delamanid interaction managed?
What your care team may do: Because the guidance on file is to avoid using these two together, your prescriber may consider an alternative to one of them. If both are needed, they may monitor you more closely, including checking your heart rhythm (ECG) and your blood levels of potassium and magnesium. What you can do: Keep taking both exactly as prescribed unless your doctor tells you otherwise. T… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Sertraline or Delamanid need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: ZOLOFT oral tablets, oral solution, sertraline hydrochloride oral tablets, oral solution. Viatris Specialty LLC (per FDA), Morgantown, WV, 2023. DailyMed
Keep reading about Sertraline
Keep reading about Delamanid
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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