Sertraline and Dordaviprone: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Sertraline
No brand names on recordDordaviprone
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Here's what's going on. Both sertraline (an antidepressant) and dordaviprone (a cancer medicine) can affect your heart's electrical rhythm in a way doctors call QT prolongation. When two medicines that do this are taken together, the effect can add up, which in rare cases can lead to an irregular heartbeat.
The good news is this is a known, manageable concern. Your care team can check your heart with an EKG and review your blood minerals before and during treatment. Please don't stop or change either medicine on your own. Just talk with your doctor or pharmacist so they can watch you closely and keep you safe.
Interaction: Additive QT/QTc prolongation when sertraline is combined with dordaviprone, with increased risk of QTc-associated arrhythmias.
- Mechanism: Pharmacodynamic additive effect on cardiac repolarization; dordaviprone causes concentration-dependent QTc prolongation. Neither drug is a prodrug here; this is a PD interaction, not enzymatic.
- Direction/magnitude: Increased QTc; magnitude not quantified.
- Evidence: Theoretical; severity rated major.
- Management: Avoid concomitant use if possible. If unavoidable, obtain baseline ECG and electrolytes, correct K+/Mg2+, and monitor periodically. Interrupt or reduce dordaviprone dose if QTc prolongs; discontinue for life-threatening arrhythmia.
What happens
An increased risk of QT interval prolongation
Interaction Deep Dive
Because it may lead to additive prolongation of the QT interval, dordaviprone should not be used together with agents known to prolong the QT interval. Dordaviprone produces QTc interval prolongation that is concentration dependent and can also heighten the likelihood of arrhythmias linked to QTc. When their combined use is unavoidable, the timing of dordaviprone and the QT prolonging medication should be spaced apart. ECGs and electrolytes should be checked before dordaviprone is initiated and then at intervals throughout therapy. For patients who experience QT prolongation, dordaviprone should be interrupted or its dose lowered, and it should be stopped permanently in patients showing indications of life-threatening arrhythmias1.
Why it happens (mechanism)
Additive QT interval prolongation
How to manage this interaction
What your care team may do:
- Prefer avoiding the combination when a reasonable alternative exists.
- If both are needed, check an ECG and blood electrolytes (like potassium and magnesium) before starting dordaviprone and periodically after.
- Adjust or briefly interrupt the dordaviprone dose if your QT interval lengthens, individualized to you.
What you can do: Keep taking both exactly as prescribed unless told otherwise. Ask your pharmacist or prescriber before adding any new medicine, and report symptoms like fainting, palpitations, or dizziness right away.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Sertraline and Dordaviprone together?
Taking sertraline with dordaviprone can add up to prolong the QT interval, so your care team will likely monitor your heart rhythm and electrolytes closely; don't change either medicine on your own. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Sertraline and Dordaviprone interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Sertraline and Dordaviprone interaction managed?
What your care team may do: Prefer avoiding the combination when a reasonable alternative exists. If both are needed, check an ECG and blood electrolytes (like potassium and magnesium) before starting dordaviprone and periodically after. Adjust or briefly interrupt the dordaviprone dose if your QT interval lengthens, individualized to you. What you can do: Keep taking both exactly as prescribed un… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Sertraline or Dordaviprone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: MODEYSO(TM) oral capsules, dordaviprone oral capsules. Jazz Pharmaceuticals, Inc. (per manufacturer), Palo Alto, CA, 2025. DailyMed
Keep reading about Sertraline
Keep reading about Dordaviprone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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