Drug Interaction Report

Sertraline and Sparsentan: Interaction Details

A pharmacist-reviewed analysis of the Sertraline and Sparsentan interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Sertraline

No brand names on record
+

Sparsentan

Filspari
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Jul 2, 2026
Editorial policy · Data sources
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Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 532 documented Sertraline interactions, 18 are rated moderate — including this one.
At a glance + Theoretical Effects may be weaker
The Bottom Line
Sparsentan may speed up how your body clears sertraline, which could make the sertraline slightly less effective, though this is theoretical. Keep taking both as prescribed and let your care team know if your symptoms return so they can adjust the dose if needed.

You've been prescribed sertraline (an antidepressant, sometimes used for anxiety) along with sparsentan (Filspari), a kidney medication. Sertraline is partly broken down by a liver enzyme called CYP2C19. Sparsentan can speed up that enzyme, which means your body may clear sertraline a little faster than usual. In theory, that could make the sertraline work a bit less well over time.

Please note this is based on theory, not on strong real-world studies, so it may not cause any noticeable change for you. The good news is your care team can watch how well your mood or anxiety symptoms are controlled and adjust your dose if needed. Keep taking both as prescribed and share any concerns.

Mechanism: Sparsentan is a CYP2C19 inducer; sertraline is partly metabolized by CYP2C19. Induction may increase sertraline clearance, lowering its plasma exposure (AUC/Cmax) and potentially reducing antidepressant/anxiolytic efficacy.

  • Direction: Reduced sertraline exposure and effect (neither drug is an affected prodrug here).
  • Magnitude: Not quantified.
  • Onset: Unspecified (enzyme induction is typically delayed, developing over days to weeks).
  • Evidence: Theoretical.
  • Management: Monitor clinical response (mood, anxiety symptoms). Titrate sertraline dose as clinically indicated. Reassess if efficacy declines after starting or stopping sparsentan.
Onset
unspecified
Evidence
theoretical
Severity
Moderate

What happens

Reduced CYP2C19 substrate exposure and reduced efficacy of CYP2C19 substrate

Interaction Deep Dive

When sparsentan, a CYP2C19 inducer, is given together with CYP2C19 substrates, the exposure to those substrates may decrease, potentially lowering the effectiveness associated with them. Watch for the efficacy of CYP2C19 substrates and adjust the dose if needed1.

Why it happens (mechanism)

Induction of CYP2C19-substrate metabolism by sparsentan

How to manage this interaction

Here's how a care team typically handles this:

  • Keep taking both medications as prescribed. Do not start, stop, or change doses on your own.
  • Watch how well the sertraline is working. Your team may monitor your mood or anxiety symptoms more closely, especially after starting sparsentan.
  • Dose can be tailored. If your symptoms seem less controlled, your sertraline dose may need to be adjusted and individualized by your care team.

Tell your pharmacist or prescriber if you notice returning depression or anxiety symptoms, or any changes after either medication is started or stopped.

Management is individual — confirm any change with your pharmacist or prescriber.

Common questions

Can I take Sertraline and Sparsentan together?

Sparsentan may speed up how your body clears sertraline, which could make the sertraline slightly less effective, though this is theoretical. Keep taking both as prescribed and let your care team know if your symptoms return so they can adjust the dose if needed. Always confirm with your pharmacist or prescriber before making any change.

How serious is the Sertraline and Sparsentan interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How is the Sertraline and Sparsentan interaction managed?

Here's how a care team typically handles this: Keep taking both medications as prescribed. Do not start, stop, or change doses on your own. Watch how well the sertraline is working. Your team may monitor your mood or anxiety symptoms more closely, especially after starting sparsentan. Dose can be tailored. If your symptoms seem less controlled, your sertraline dose may need to be adjusted and indi… Management is individual — always follow your own care team's guidance.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Sertraline or Sparsentan need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (1)

  1. Product Information: FILSPARI® oral tablets, sparsentan oral tablets. Travere Therapeutics Inc, San Diego, CA, 2026. DailyMed
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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Sertraline + Activated Charcoal American Hellebore Arsenic Cesium Ephedra Grapefruit Lithium Sida Cordifolia + 180 more
Sparsentan + Activated Charcoal Beer Grapefruit Siberian Cocklebur St. John's Wort Wine Acacia Rigidula Adrafinil + 164 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.