Sertraline

532 interactions 409 explained in plain English 979 cited references

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sparfloxacin Fluconazole Furazolidone Toloxatone Thioridazine Terfenadine

36 Contraindicated 477 Major 18 Moderate 1 Minor

All (532) Contraindicated (36) Major (477) Moderate (18) Minor (1)

Major

Sertraline Eribulin Injection Halaven An increased risk of QT interval prolongation Details Sertraline Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Sertraline Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Sertraline Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Sertraline Fondaparinux Injection Arixtra An increased risk of bleeding Details Sertraline Foscarnet Injection Foscavir An increased risk of QT interval prolongation Details Sertraline Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Sertraline Goserelin Implant Zoladex An increased risk of QT interval prolongation Details Sertraline Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Granisetron Injection Granisol Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Sertraline Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Sertraline Histrelin Implant Supprelin An increased risk of QT interval prolongation Details Sertraline Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Sertraline Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Sertraline Inotuzumab Ozogamicin Injection Besponsa An increased risk of QT interval prolongation Details Sertraline Ketorolac Injection Acular An increased risk of bleeding Details Sertraline Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Sertraline Ketorolac Ophthalmic Acular An increased risk of bleeding Details Sertraline Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Sertraline Levofloxacin Injection Levaquin An increased risk of QT interval prolongation Details Sertraline Lithium Carbonate Lithobid An increased risk of serotonin syndrome Details Sertraline Meloxicam Injection Alloxate An increased risk of bleeding Details Sertraline Methylphenidate Transdermal Patch Daytrana Increased selective serotonin reuptake inhibitor exposure Details Sertraline Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Sertraline Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Sertraline Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Sertraline Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Sertraline Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Sertraline Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Sertraline Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation Details Sertraline Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Sertraline Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Sertraline Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Sertraline Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Sertraline Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Sertraline Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Sertraline Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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