Sertraline

532 interactions 409 explained in plain English 979 cited references
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sparfloxacin Fluconazole Furazolidone Toloxatone Thioridazine Terfenadine
36 Contraindicated 477 Major 18 Moderate 1 Minor
All (532) Contraindicated (36) Major (477) Moderate (18) Minor (1)

Moderate

Sertraline Alprazolam Xanax Explained An increased risk of psychomotor impairment and sedation Details Sertraline Cimetidine Tagamet Explained Elevated sertraline serum concentrations and increased risk of adverse side effects Details Sertraline Dehydroepiandrosterone Intrarosa Explained Development of manic symptoms Details Sertraline Desmopressin DDAVP Explained Increased risk of water intoxication with hyponatremia Details Sertraline Dihydroergotamine Brekiya Explained An increased risk of weakness, hyperreflexia and incoordination Details Sertraline Fluphenazine Explained An increased risk of developing acute parkinsonism Details Sertraline Ginkgo Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sertraline Lamotrigine Lamictal Explained An increased risk of lamotrigine toxicity (fatigue, sedation, confusion, decreased cognition) Details Sertraline Lumateperone Caplyta An increased risk for serotonin reuptake inhibitor (SRI)-associated adverse reactions Details Sertraline Mavacamten Camzyos Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Sertraline Propranolol Hemangeol Explained Increased propranolol exposure Details Sertraline Rifampin Rifadin Explained Loss of sertraline efficacy Details Sertraline Rilzabrutinib Wayrilz Explained Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Sertraline Sparsentan Filspari Explained Reduced CYP2C19 substrate exposure and reduced efficacy of CYP2C19 substrate Details Sertraline Tipranavir Aptivus Explained Increased sertraline plasma concentrations Details Sertraline Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Sertraline Dihydroergotamine Injection DHE-45® Injection An increased risk of weakness, hyperreflexia and incoordination Details Sertraline Dihydroergotamine Nasal Spray Migranal An increased risk of weakness, hyperreflexia and incoordination Details

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