Lumateperone and Sertraline: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Sertraline
No brand names on recordLumateperone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk for serotonin reuptake inhibitor (SRI)-associated adverse reactions
Interaction Deep Dive
Concomitant use of lumateperone with serotonin reuptake inhibitor (SRI) may increase the risk of SRI-associated adverse reactions. Increased monitoring for serotonin reuptake inhibitor (SRI)-associated adverse reactions is recommended when serotonin norepinephrine reuptake inhibitor (SNRIs)/SSRIs are used in combination with lumateperone (due its a moderate serotonin transporter (SERT) activity)1.
Why it happens (mechanism)
Additive serotonin reuptake inhibitor (SRI)-effects
Common questions
Can I take Lumateperone and Sertraline together?
An increased risk for serotonin reuptake inhibitor (SRI)-associated adverse reactions Always confirm with your pharmacist or prescriber before making any change.
How serious is the Lumateperone and Sertraline interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Lumateperone or Sertraline need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: CAPLYTA® oral capsules, lumateperone oral capsules. Intra-Cellular Therapies Inc (per manufacturer), Bedminster, NJ, 2025. DailyMed
Keep reading about Sertraline
Keep reading about Lumateperone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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