Lumateperone

188 interactions 331 cited references

Also sold as: Caplyta Caplyta®

About Lumateperone

Lumateperone is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Lumateperone is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substan… Read the full Lumateperone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Topiramate Thioridazine Ticagrelor Ticlopidine Tovorafenib

1 Contraindicated 166 Major 21 Moderate

All (188) Contraindicated (1) Major (166) Moderate (21)

Contraindicated

Lumateperone Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details

Major

Lumateperone Abametapir Increased exposure of CYP3A4 substrate Details Lumateperone Relugolix Orgovyx Reduced lumateperone exposure Details Lumateperone Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Lumateperone Bexarotene Targretin Reduced lumateperone exposure Details Lumateperone Bexarotene Topical Targretin Reduced lumateperone exposure Details Lumateperone Brigatinib Alunbrig Reduced lumateperone exposure Details Lumateperone Brivaracetam Briviact Reduced lumateperone exposure Details Lumateperone Brivaracetam Injection Briviact Reduced lumateperone exposure Details Lumateperone Darolutamide Nubeqa Reduced lumateperone exposure Details Lumateperone Dexamethasone Injection Decadron Reduced lumateperone exposure Details Lumateperone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced lumateperone exposure Details Lumateperone Enasidenib Idhifa Reduced lumateperone exposure Details Lumateperone Encorafenib Braftovi Reduced lumateperone exposure Details Lumateperone Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Lumateperone Ketoconazole Topical Extina® Foam Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Lumateperone Lefamulin Xenleta Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Lenacapavir Injection Sunlenca Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Lenacapavir Oral Sunlenca Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Letermovir Injection Prevymis Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Lumateperone Adagrasib Krazati Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Lumateperone Alfentanil Increased ALfentanil exposure and an increased risk of respiratory depression Details Lumateperone Amprenavir Altered (reduced/increased) lumateperone exposure and an increased risk of lumateperone-related adverse reaction Details Lumateperone Apalutamide Erleada Reduced lumateperone exposure Details Lumateperone Aprepitant Aponvie Altered (reduced/increased) lumateperone exposure and an increased risk of lumateperone-related adverse reaction Details Lumateperone Armodafinil Nuvigil Reduced lumateperone exposure Details Lumateperone Artemether Increased artemether/lumefantrine exposure, an increased risk of QT prolongation, reduced CYP3A4 substrate exposure and reduced ef... Details Lumateperone Atazanavir Reyataz Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Avacopan Tavneos Increased CYP3A4 substrate exposure Details Lumateperone Belzutifan Welireg Reduced lumateperone exposure Details Lumateperone Berotralstat Orladeyo Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Boceprevir Altered (reduced/increased) lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Lumateperone Bosentan Reduced lumateperone exposure Details Lumateperone Carbamazepine Carbatrol Reduced lumateperone exposure Details Lumateperone Cenobamate Xcopri Reduced lumateperone exposure Details Lumateperone Ceritinib Zykadia Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Lumateperone Ciprofloxacin Increased lumateperone exposure, an increased risk of lumateperone-related adverse events and an increased risk of QT interval pro... Details Lumateperone Clarithromycin Biaxin Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Lumateperone Clobazam Onfi Reduced lumateperone exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.