Lumateperone

Name: Lumateperone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

188 interactions 331 cited references

Also sold as: Caplyta Caplyta®

About Lumateperone

Lumateperone is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Lumateperone is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substan… Read the full Lumateperone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Topiramate Thioridazine Ticagrelor Ticlopidine Tovorafenib

1 Contraindicated 166 Major 21 Moderate

All (188) Contraindicated (1) Major (166) Moderate (21)

Contraindicated

Lumateperone Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.