Bee Venom - Caplyta (Lumateperone) Interaction
Herbal: Bee Venom
Also Known As: Apis Venenum Purum, Apitoxin, Apitoxine, Pure Bee Venom, Yellow Hornet, Yellow-Jacket Venom
Drug: Lumateperone
Brand names:
Caplyta
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Lumateperone is classified as belonging to the following category: Immunosuppressants
Bee venom might stimulate immune system activity.Theoretically, bee venom might interfere with immunosuppressant therapy. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Cuende E, Fraguas J, Pena JE, et al. Beekeepers' arthropathy. J Rheumatol 1999;26:2684-90.
- Bomalaski JS, Ford T, Hudson AP, Clark MA. Phospholipase A2-activating protein induces the synthesis of IL-1 and TNF in human monocytes. J Immunol 1995;154:4027-31.
Bee Venom Overview
Bee venom, a liquid produced by honeybee glands, is used in traditional medicine in Asia, eastern Europe, and South America. It contains melittin, which is believed to have therapeutic effects, and phospholipase A2 (PLA2), a major antigen responsible for adverse effects. Other components include serotonin, hyaluronidase, and histamine. PLA2 causes smooth muscle contraction and blood pressure reduction. Bee venom stimulates an allergenic response and decreases leukocyte sensitivity, making it useful for desensitization to bee stings. However, it also has pro-inflammatory effects and can sensitize nociceptor cells, inducing pain.
Lumateperone Overview
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Lumateperone is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Lumateperone is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.
Bee Venom - More Interactions
Bee Venom interacts with 112 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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