Bee Venom + Metoprolol
Metoprolol brand names: Lopressor, Toprol XL.
We found no known interaction between Bee Venom and Metoprolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Metoprolol states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Bee Venom and Metoprolol
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Metoprolol and Bee Venom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Bee Venom safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Metoprolol
Interactions in our licensed database are recorded against drug classes, not just single drug names. Metoprolol is filed under 6 classifications — including beta-blockers, antihypertensive drugs, cytochrome p450 2d6 (cyp2d6) substrates. Bee Venom has documented interactions with 1 drug class — the most serious being immunosuppressants (moderate) — and none of Metoprolol’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Bee Venom Does Interact With Other Medications
Bee Venom has 121 moderate known drug interactions in our database — Metoprolol isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Bee Venom
We haven’t checked that one against Bee Venom yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Bee Venom. Pick one to open its full report.
Bee Venom in Pregnancy & Breastfeeding
When used by subcutaneous injection by a trained medical professional. Significant adverse effects to fetus or mother have not been reported. However, some clinicians decrease maintenance dose by half during pregnancy.
When used by subcutaneous injection in high doses. High doses of bee venom can increase release of histamine, which can cause uterine contraction; avoid using in high doses.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Metoprolol Products Have a Food Rule — Bee Venom Should Not Break It
At least one FDA label for a product containing Metoprolol says to take it with food. If you take Bee Venom on an empty stomach out of habit, keep them separate — and take Metoprolol with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Metoprolol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Administer once daily with food or after a meal.
From the Dosage and Administration section of the FDA label we read for Metoprolol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Bee Venom or Metoprolol
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Bee Venom or Metoprolol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Does MCT Oil Interact With Amlodipine or Metoprolol? ›
- Concerns Taking Metoprolol With Saw Palmetto ›
- Concerns With Taking Both Metoprolol and Propafenone ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Metoprolol
This page covers Bee Venom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metoprolol page lists 183 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).
By severity: 5 major · 152 moderate · 26 minor.
From our pharmacist’s overview on the Metoprolol page
“With metoprolol (Lopressor, Toprol XL), a beta-blocker for high blood pressure and heart problems, these interactions deserve genuine care, starting with the five rated major. Most entries pull blood pressure one way or the other: many supplements add to metoprolol's lowering effect and can drop pressure too far, while a few, tyramine…”
Reviewed by 2 · Jul 18, 2026
Taking Bee Venom as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2 real supplement products containing Bee Venom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bee Venom. Even though Bee Venom itself has no known interaction with Metoprolol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Bee Venom and Metoprolol Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#669 of 1,452 supplements looked up here in the last 7 days
#7 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bee Venom reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bee Venom and Metoprolol records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Bee Venom
What is Bee Venom?
- Joint pain and arthritis
- Muscle and nerve pain
- Bee sting allergy desensitization
- Skin and cosmetic uses
- Multiple sclerosis (traditional/alternative use)
Bee venom is a complex mixture of proteins and other compounds taken from honeybees and used in traditional medicine for pain and inflammation, and in conventional medicine for allergy shots to prevent severe sting reactions. Outside of supervised allergy treatment, strong evidence for its benefits is lacking, and it can cause serious allergic reactions, so it should only be used under medical supervision.
Venom secreted by the venom gland of the honeybee (Apis mellifera) · Purified injectable venom, bee sting therapy (live bees), creams and ointments, allergy desensitization extracts, some cosmetic products
An interaction check asks whether these two react with each other — it does not ask whether Bee Venom is a good idea for someone in your situation. Here is what our Bee Venom record says about it on its own.
Bee Venom: dosing
There is no standard, well-established dose of bee venom for general use. When it is used for allergy desensitization, an allergy specialist carefully chooses and adjusts the dose in a controlled setting.For over-the-counter creams or other products, follow the directions on the label. Do not try to treat yourself with live bee stings or injectable venom on your own.
From our Bee Venom monograph — the full record covers uses, side effects and every documented interaction.
About Metoprolol
What Is Metoprolol Used For?
Brand names: Lopressor, Toprol XL
Metoprolol is used to treat several heart and blood pressure conditions. Metoprolol succinate extended-release tablets (including Toprol-XL) are approved for high blood pressure, angina pectoris (chest pain from the heart), and heart failure. Metoprolol tartrate tablets (including Lopressor) are approved for high blood pressure, angina, and — when used alongside intravenous metoprolol — to reduce the risk of cardiovascular death after a definite or suspected heart attack.
Metoprolol tartrate injection (intravenous form) is used in hemodynamically stable patients with a definite or suspected acute heart attack to reduce cardiovascular death, and is followed by oral metoprolol therapy. Lowering blood pressure with metoprolol reduces the risk of strokes and heart attacks.
Most-Reported Side Effects for Metoprolol
From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Bee Venom
Browse every other medication we’ve checked against Bee Venom — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
121 interactions
- Hydrocortisone ›
- Prednisone ›
- Cyclosporine ›
- Dexamethasone ›
- Prednisolone ›
- Tacrolimus ›
- Triamcinolone ›
- Betamethasone ›
- Ciclesonide ›
- Azathioprine ›
- Beclomethasone ›
- Beclomethasone Dipropionate ›
- Cladribine ›
- Cortisone Acetate ›
- Cyclophosphamide ›
- Daclizumab ›
- Denosumab ›
- Fingolimod ›
- Methylprednisolone ›
- Tofacitinib ›
- Triamcinolone Acetonide ›
- 6-mercaptopurine ›
- Abatacept ›
- Abrocitinib ›
- Adalimumab ›
- Adalimumab-adaz ›
- Adalimumab-adbm ›
- Adalimumab-afzb ›
- Adalimumab-atto ›
- Adalimumab-bwwd ›
- Adalimumab-fkjp ›
- Alefacept ›
- Alemtuzumab ›
- Anifrolumab-fnia ›
- Antithymocyte Globulin ›
- Atezolizumab ›
- Azamune ›
- Basiliximab ›
- Beclometasone Dipropionate ›
- Betamethasone Dipropionate ›
- Betamethasone Valerate ›
- Bimekizumab-bkzx ›
- Cisplatin ›
- Copanlisib ›
- Deflazacort ›
- Deucravacitinib ›
- Diroximel Fumarate ›
- Durvalumab ›
- Eculizumab ›
- Efalizumab ›
- Efgartigimod Alfa-fcab ›
- Elranatamab ›
- Emapalumab-lzsg ›
- Epcoritamab-bysp ›
- Etanercept ›
- Etanercept-szzs ›
- Etanercept-ykro ›
- Etrasimod ›
- Fludrocortisone ›
- Fluorouracil (iv) ›
Showing 60 of 121 moderate interactions — see all 121 on the Bee Venom page.
No interaction 2,708 drugs checked — show the list
We also checked Bee Venom against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Bee Venom list.
Bee Venom References
The 35 references that drive our Bee Venom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Mosbech H, Muller U. Side-effects of insect venom immunotherapy: results from an EAACI multicenter study. Allergy 2000;55:1005-10. DOI
- Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
- de Jong NW, Vermeulen AM, de Groot H. Allergy to bumblebee venom. III. Immunotherapy follow-up study (safety and efficacy) in patients with occupational bumblebee-venom anaphylaxis. Allergy 1999;54:980-4. PubMed
- Cuende E, Fraguas J, Pena JE, et al. Beekeepers' arthropathy. J Rheumatol 1999;26:2684-90.
- Caldwell JR. Venoms, copper, and zinc in the treatment of arthritis. Rheum Dis Clin North Am 1999;25:919-28. PubMed
- Petroianu G, Liu J, Helfrich U, et al. Phosholipase A2-induced coagulation abnormalities after bee sting. Am J Emerg Med 2000;18:22-7.
- Birnbaum J, Charpin D, Vervloet D. Rapid hymenoptera venom immunotherapy: comparative safety of three protocols. Clin Exp Allergy 1993;23:226-30. PubMed
- Bomalaski JS, Ford T, Hudson AP, Clark MA. Phospholipase A2-activating protein induces the synthesis of IL-1 and TNF in human monocytes. J Immunol 1995;154:4027-31. DOI
- Li JT, Yunginger JW. Management of insect sting hypersensitivity. Mayo Clin Proc 1992;67:188-94. PubMed
- Golden DB, Kagey-Sobotka A, Lichtenstein LM. Survey of patients after discontinuing venom immunotherapy. J Allergy Clin Immunol 2000;105(2 Pt 1):385-90. PubMed
- Bousquet J, Muller UR, Dreboro S, et al. Immunotherapy with hymenoptera venoms. Allergy 1987;42:401-13. DOI
- Ewan PW. ABC of allergies. Venom allergy. BMJ 1998;316:1365-8.
- Alford C, Cox H, Wescott R. The effects of red bull energy drink on human performance and mood. Amino Acids 2001;21:139-50. PubMed
- Horwitz RI, Daniels SR. Bias or biology: evaluating the epidemiologic studies of L-tryptophan and the eosinophilia-myalgia syndrome. J Rheumatol Suppl 1996;46:60-72.
- Wesselius T, Heersema DJ, Mostert JP, et al. A randomized crossover study of bee sting therapy for multiple sclerosis. Neurology 2005;65:1764-8. PubMed
- Cho SY, Shim SR, Rhee HY, et al. Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson's disease. Parkinsonism Relat Disord. 2012;18(8):948-52. PubMed
- Doo KH, Lee JH, Cho SY, et al. A Prospective Open-Label Study of Combined Treatment for Idiopathic Parkinson's Disease Using Acupuncture and Bee Venom Acupuncture as an Adjunctive Treatment. J Altern Complement Med. 2015;21(10):598-603. PubMed
- Hartmann A, Müllner J, Meier N, et al. Bee Venom for the Treatment of Parkinson Disease - A Randomized Controlled Clinical Trial. PLoS One. 2016;11(7):e0158235. PubMed
- Koh PS, Seo BK, Cho NS, Park HS, Park DS, Baek YH. Clinical effectiveness of bee venom acupuncture and physiotherapy in the treatment of adhesive capsulitis: a randomized controlled trial. J Shoulder Elbow Surg. 2013;22(8):1053-62. PubMed
- Lee HJ, Park IS, Lee JI, Kim JS. Guillain-Barré syndrome following bee venom acupuncture. Intern Med. 2015;54(8):975-8.
- Lim SM, Lee SH. Effectiveness of bee venom acupuncture in alleviating post-stroke shoulder pain: a systematic review and meta-analysis. J Integr Med. 2015;13(4):241-7. PubMed
- Park JH, Yim BK, Lee JH, Lee S, Kim TH. Risk associated with bee venom therapy: a systematic review and meta-analysis. PLoS One. 2015;10(5):e0126971. PubMed
- Senel E, Holt S, Demir E. Treatment of notalgia paresthetica with bee venom and capsaicin: a pilot study with 20 patients. Skinmed 2019;17(6):370-2.
- Conrad VJ, Hazan LL, Latorre AJ, Jakubowska A, Kim CMH. Efficacy and safety of honey bee venom (Apis mellifera) dermal injections to treat osteoarthritis knee pain and physical disability: a randomized controlled trial. J Altern Complement Med 2019;25(8):
- Cho SY, Lee YE, Doo KH, et al. Efficacy of combined treatment with acupuncture and bee venom acupuncture as an adjunctive treatment for Parkinson's disease. J Altern Complement Med 2018;24(1):25-32. PubMed
- Rosman Y, Nashef F, Cohen-Engler A, Meir-Shafrir K, Lachover-Roth I, Confino-Cohen R. Exclusive bee venom allergy: risk factors and outcome of immunotherapy. Int Arch Allergy Immunol 2019;180(2):128-34. PubMed
- Lee EJ, Ahn YC, Kim YI, Oh MS, Park YC, Son CG. Incidence rate of hypersensitivity reactions to bee-venom acupuncture. Front Pharmacol 2020;11:545555. PubMed
- Shen L, Lee JH, Joo JC, Park SJ, Song YS. Bee venom acupuncture for shoulder pain: a systematic review and meta-analysis of randomized controlled trials. J Pharmacopuncture 2020;23(2):44-53. PubMed
- Park YC, Koh PS, Seo BK, et al. Long-term effectiveness of bee venom acupuncture and physiotherapy in the treatment of adhesive capsulitis: a one-year follow-up analysis of a previous randomized controlled trial. J Altern Complement Med 2014;20(12):919-24 PubMed
- Lee B, Seo BK, Kwon OJ, Jo DJ, Lee JH, Lee S. Effect of Combined Bee Venom Acupuncture and NSAID Treatment for Non-Specific Chronic Neck Pain: A Randomized, Assessor-Blinded, Pilot Clinical Trial. Toxins (Basel) 2021;13(7):436. PubMed
- Kim K, Jeong H, Lee G, Jang S, Yook T. Characteristics of Adverse Events in Bee Venom Therapy Reported in South Korea: A Survey Study. Toxins (Basel) 2021;14(1):18. PubMed
- Yoo SA, Park HE, Kim M. A Case of Newly Developed Pemphigus Foliaceus and Possible Association with Alternative Bee-Venom Therapy. Ann Dermatol 2021;33(5):467-469. PubMed
- Waziri B, Alhaji UI, Oduwale MA, Umar HI, Abdulmalik AM. A rare concurrence: bee venom associated acute tubular necrosis and acute interstitial nephritis. Oxf Med Case Reports 2022;5:167-70. PubMed
- Chang MC. Persistent severe muscle pain following mistakenly injected high-dose bee venom: A care-compliant case report. Medicine (Baltimore) 2022;101(49):e32180. PubMed
- Park JH, Kim JG, Cha SH, Park SD. Eosinophilic foreign body granuloma after multiple self-administered bee stings. Br J Dermatol 1998,139(6):1102-5. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Metoprolol Is Linked to Lower Levels of One Nutrient
Natural Medicines records Metoprolol as a medicine that can lower these. This is not an interaction with Bee Venom — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Metoprolol nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Bee Venom and Metoprolol Together: Common Questions
Is it safe to take Bee Venom with Metoprolol?
Do Bee Venom and Metoprolol have any of the same side effects?
Should I take Bee Venom and Metoprolol at the same time of day?
How was the Bee Venom and Metoprolol combination checked?
Does Bee Venom interact with any other medications?
Does Metoprolol interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Metoprolol and Bee Venom?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.