Lumateperone

188 interactions 331 cited references

Also sold as: Caplyta Caplyta®

About Lumateperone

Lumateperone is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Lumateperone is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substan… Read the full Lumateperone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Topiramate Thioridazine Ticagrelor Ticlopidine Tovorafenib

1 Contraindicated 166 Major 21 Moderate

All (188) Contraindicated (1) Major (166) Moderate (21)

Major

Lumateperone Clofazimine Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Cobicistat Tybost Increased lumateperone exposure, an increased risk of lumateperone-related adverse reactions, an increased cobicistat exposure and... Details Lumateperone Conivaptan Vaprisol Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Crizotinib Xalkori Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Dabrafenib Tafinlar Reduced lumateperone exposure Details Lumateperone Darunavir Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Dexamethasone Reduced lumateperone exposure Details Lumateperone Dicloxacillin Reduced lumateperone exposure Details Lumateperone Diltiazem Cardizem Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Dipyrone Reduced lumateperone exposure Details Lumateperone Dronedarone Multaq Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Duvelisib Copiktra Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Echinacea Reduced lumateperone exposure Details Lumateperone Efavirenz Reduced lumateperone exposure Details Lumateperone Elafibranor Iqirvo Reduced lumateperone exposure Details Lumateperone Elagolix Orilissa Reduced lumateperone exposure Details Lumateperone Enzalutamide Xtandi Reduced lumateperone exposure Details Lumateperone Erythromycin Erythrocin Stearate Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Eslicarbazepine Acetate Aptiom Reduced lumateperone exposure Details Lumateperone Etravirine Intelence Reduced lumateperone exposure Details Lumateperone Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Lumateperone Fexinidazole An increased CYP3A4 substrate exposure Details Lumateperone Fluconazole Diflucan Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Fosamprenavir Lexiva Altered (reduced/increased) lumateperone exposure and an increased risk of lumateperone-related adverse reaction Details Lumateperone Fosnetupitant Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Fosphenytoin Cerebyx Reduced lumateperone exposure Details Lumateperone Garlic Reduced lumateperone exposure Details Lumateperone Ginkgo Reduced lumateperone exposure Details Lumateperone Ginseng Reduced lumateperone exposure Details Lumateperone Haloperidol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Lumateperone Idelalisib Zydelig Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Lumateperone Imatinib Gleevec Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Indinavir Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Lumateperone Insulin Afrezza Reduced blood glucose lowering effect of insulin Details Lumateperone Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Lumateperone Insulin Glargine, Recombinant Basaglar An increased risk of hypoglycemia Details Lumateperone Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Lumateperone Isavuconazole Altered (reduced/increased) lumateperone exposure and an increased risk of lumateperone-related adverse reaction Details Lumateperone Isavuconazonium Cresemba Altered (reduced/increased) lumateperone exposure and an increased risk of lumateperone-related adverse reaction Details Lumateperone Itraconazole Sporanox Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.