Lumateperone

188 interactions 331 cited references
Also sold as: Caplyta Caplyta®
About Lumateperone

Lumateperone is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Lumateperone is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substan… Read the full Lumateperone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Lumateperone Ivosidenib Tibsovo Reduced lumateperone exposure Details Lumateperone Ketoconazole Extina Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Lumateperone Lemborexant Dayvigo Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Lumateperone Lenacapavir Sunlenca Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Lesinurad Reduced lumateperone exposure Details Lumateperone Letermovir Prevymis Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Lomitapide Increased lomitapide exposure Details Lumateperone Lonafarnib Zokinvy Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Lumateperone Lopinavir Reduced lumateperone exposure Details Lumateperone Lorlatinib Lorbrena Reduced lumateperone exposure Details Lumateperone Lumacaftor Reduced lumateperone exposure Details Lumateperone Methylergonovine Methergine Increased methylergonovine exposure Details Lumateperone Methylprednisolone Depo-Medrol Reduced lumateperone exposure Details Lumateperone Mifepristone Korlym Increased CYP3A4 substrate exposure and an increased miFEPRIStone exposure Details Lumateperone Mitapivat Aqvesme Reduced lumateperone exposure Details Lumateperone Mitotane Lysodren Reduced lumateperone exposure Details Lumateperone Mobocertinib Exkivity Reduced lumateperone exposure Details Lumateperone Modafinil Provigil Reduced lumateperone exposure Details Lumateperone Nafcillin Reduced lumateperone exposure Details Lumateperone Nefazodone Increased lumateperone exposure and an increased risk of lumateperone-associated adverse reactions Details Lumateperone Nelfinavir Viracept Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Lumateperone Netupitant Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Nevirapine Viramune Reduced lumateperone exposure Details Lumateperone Nifedipine Adalat® Increased NIFEdipine exposure Details Lumateperone Nilotinib Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Nirmatrelvir Increased lumateperone exposure Details Lumateperone Nirogacestat Ogsiveo Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Lumateperone Omaveloxolone Skyclarys Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Lumateperone Oritavancin Reduced lumateperone exposure Details Lumateperone Oxcarbazepine Oxtellar Reduced lumateperone exposure Details Lumateperone Paritaprevir Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Lumateperone Pexidartinib Turalio Reduced lumateperone exposure Details Lumateperone Phenobarbital Fidoquel Reduced lumateperone exposure Details Lumateperone Phenytoin Dilantin Reduced lumateperone exposure Details Lumateperone Pimozide Increased pimozide exposure Details Lumateperone Pioglitazone Actos Reduced lumateperone exposure Details Lumateperone Pitolisant Wakix Reduced lumateperone exposure Details Lumateperone Posaconazole Noxafil Increased lumateperone exposure and an increased risk of lumateperone-related adverse reactions Details Lumateperone Prednisone Deltasone Reduced lumateperone exposure Details Lumateperone Pretomanid Reduced lumateperone exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.