Sertraline

532 interactions 409 explained in plain English 979 cited references

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sparfloxacin Fluconazole Furazolidone Toloxatone Thioridazine Terfenadine

36 Contraindicated 477 Major 18 Moderate 1 Minor

All (532) Contraindicated (36) Major (477) Moderate (18) Minor (1)

Contraindicated

Sertraline Bepridil Explained An increased risk of QT interval prolongation Details Sertraline Bromopride Explained Increased risk of extrapyramidal reactions Details Sertraline Cisapride Propulsid® Explained Increased risk of QT interval prolongation Details Sertraline Disulfiram Antabuse An increased risk of a disulfiram-alcohol reaction Details Sertraline Dronedarone Multaq Explained Increased risk of QT interval prolongation Details Sertraline Ensitrelvir Explained Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Sertraline Fluconazole Diflucan Explained Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Sertraline Furazolidone Explained Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Sertraline Iproniazid Explained CNS toxicity or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sertraline Isocarboxazid Marplan Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) or CNS toxicit... Details Sertraline Ketoconazole Extina Explained Increased sertraline exposure and an increased risk of QT interval prolongation Details Sertraline Levoketoconazole Recorlev Explained An increased risk of QT interval prolongation and torsades pointes, an increased CYP3A4 substrate exposure and an increased risk o... Details Sertraline Linezolid Zyvox Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Sertraline Mesoridazine Explained An increased risk of QT interval prolongation Details Sertraline Methylene Blue Provayblue Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Sertraline Metoclopramide Explained Increased risk of metoclopramide exposure and an increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Sertraline Ozanimod Explained An increased risk of serotonin syndrome and an increased risk of serious adverse reactions Details Sertraline Phenelzine Nardil Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) or CNS toxicit... Details Sertraline Pimozide Explained Increased pimozide exposure, an increased risk of pimozide-related adverse events and an increased risk of QT interval prolongatio... Details Sertraline Piperaquine Explained An increased risk of QT interval prolongation Details Sertraline Posaconazole Noxafil Explained Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Sertraline Procarbazine Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) or CNS toxicit... Details Sertraline Rasagiline Azilect Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) or CNS toxicit... Details Sertraline Safinamide Xadago Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Sertraline Saquinavir Explained An increased risk of QT interval prolongation Details Sertraline Selegiline Anipryl Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) or CNS toxicit... Details Sertraline Sparfloxacin Explained An increased risk of QT interval prolongation Details Sertraline Terfenadine Explained An increased risk of QT interval prolongation Details Sertraline Thioridazine Explained An increased risk of QT interval prolongation Details Sertraline Toloxatone Explained CNS toxicity or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Sertraline Tranylcypromine Parnate Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) or CNS toxicit... Details Sertraline Ziprasidone Geodon Explained Increased risk of QT interval prolongation and an increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, men... Details Sertraline Ketoconazole Topical Extina® Foam Increased sertraline exposure and an increased risk of QT interval prolongation Details Sertraline Linezolid Injection Zyvox An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Sertraline Metoclopramide Injection Gimoti Increased risk of metoclopramide exposure and an increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Sertraline Metoclopramide Nasal Spray Gimoti Increased risk of metoclopramide exposure and an increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

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