Sevoflurane

77 interactions 5 explained in plain English

Also sold as: Petrem SevoFlo Sevospire Sojourn Ultane

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levofloxacin Injection Goserelin Implant Felbamate Alfuzosin Eribulin Injection Arsenic Trioxide

65 Major 12 Moderate

All (77) Major (65) Moderate (12)

Major

Sevoflurane Ivabradine Corlanor Increased risk of QT interval prolongation Details Sevoflurane Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Sevoflurane Lefamulin Xenleta Increased risk of QT interval prolongation Details Sevoflurane Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Sevoflurane Levofloxacin Levaquin Increased risk of QT interval prolongation Details Sevoflurane Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Sevoflurane Linezolid Injection Zyvox An increased risk of hemodynamic instability during surgery or medical procedures Details Sevoflurane Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Sevoflurane Mefloquine Lariam® Increased risk of QT interval prolongation Details Sevoflurane Methylphenidate Adhansia XR® Increased risk of sudden blood pressure and heart rate increases Details Sevoflurane Methylphenidate Transdermal Patch Daytrana Increased risk of sudden blood pressure and heart rate increases Details Sevoflurane Metronidazole Flagyl An increased risk of QT interval prolongation Details Sevoflurane Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Sevoflurane Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Sevoflurane Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Sevoflurane Moxifloxacin Avelox Increased risk of QT interval prolongation Details Sevoflurane Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Sevoflurane Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Sevoflurane Octreotide Bynfezia Increased risk of QT interval prolongation Details Sevoflurane Octreotide Injection Bynfezia Increased risk of QT interval prolongation Details Sevoflurane Ofloxacin Floxin® Increased risk of QT interval prolongation Details Sevoflurane Ofloxacin Ophthalmic Ocuflox Increased risk of QT interval prolongation Details Sevoflurane Ofloxacin Otic Floxin® Otic Increased risk of QT interval prolongation Details Sevoflurane Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Sevoflurane Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

Moderate

Sevoflurane Acetaminophen And Codeine Capital® & Codeine Explained Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Butorphanol Injection Butorphic Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Butorphanol Nasal Spray Stadol® NS Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Diazepam Nasal Spray Valtoco Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Diazepam Rectal Diastat Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Fentanyl Transdermal Patch Duragesic® Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Hydromorphone Injection Dilaudid Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Hydromorphone Rectal available generically Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Midazolam Nasal Spray Nayzilam Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Midazolam Injection Nayzilam Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Morphine Injection Astramorph® PF Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Nalbuphine Injection Nubain® Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.