Sevoflurane

77 interactions 5 explained in plain English
Also sold as: Petrem SevoFlo Sevospire Sojourn Ultane
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levofloxacin Injection Goserelin Implant Felbamate Alfuzosin Eribulin Injection Arsenic Trioxide
65 Major 12 Moderate
All (77) Major (65) Moderate (12)

Moderate

Sevoflurane Acetaminophen And Codeine Capital® & Codeine Explained Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Butorphanol Injection Butorphic Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Butorphanol Nasal Spray Stadol® NS Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Diazepam Nasal Spray Valtoco Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Diazepam Rectal Diastat Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Fentanyl Transdermal Patch Duragesic® Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Hydromorphone Injection Dilaudid Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Hydromorphone Rectal available generically Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Midazolam Nasal Spray Nayzilam Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Midazolam Injection Nayzilam Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Morphine Injection Astramorph® PF Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Sevoflurane Nalbuphine Injection Nubain® Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details

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