Sevoflurane and Hydromorphone Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Sevoflurane
Hydromorphone Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression
Interaction Deep Dive
Concomitant use of sevoflurane and opioids may reduce the minimum alveolar concentration (MAC) of sevoflurane in the same manner as with other inhalational anesthetics. Sevoflurane may cause respiratory depression, which may be augmented by opioids. However, sevoflurane administration is compatible with opioids as commonly used in surgical practice. Monitor respiration and, if necessary, assist with ventilation1.
Why it happens (mechanism)
Unknown
Common questions
Can I take Sevoflurane and Hydromorphone Injection together?
Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Always confirm with your pharmacist or prescriber before making any change.
How serious is the Sevoflurane and Hydromorphone Injection interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Sevoflurane or Hydromorphone Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: ULTANE(R) inhalation liquid, sevoflurane inhalation liquid. AbbVie Inc (per FDA), North Chicago, IL, 2022. DailyMed
Keep reading about Sevoflurane
Keep reading about Hydromorphone Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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