Hydromorphone Injection

344 interactions 466 cited references
Also sold as: Dilaudid Dilaudid-HP® Dilaudid®
About Hydromorphone Injection

Hydromorphone injection is used to relieve pain. Hydromorphone injection is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Read the full Hydromorphone Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isocarboxazid Naltrexone Phenelzine Safinamide Samidorphan Tranylcypromine
6 Contraindicated 329 Major 9 Moderate
All (344) Contraindicated (6) Major (329) Moderate (9)

Contraindicated

Hydromorphone Injection Isocarboxazid Marplan An increased risk of CNS depression Details Hydromorphone Injection Naltrexone ReVia Precipitation of opioid withdrawal symptoms; decreased opioid effectiveness Details Hydromorphone Injection Phenelzine Nardil An increased risk of serotonin syndrome Details Hydromorphone Injection Safinamide Xadago Increased risk of serotonin syndrome Details Hydromorphone Injection Samidorphan Decreased opioid efficacy and precipitation of opioid withdrawal Details Hydromorphone Injection Tranylcypromine Parnate Increased risk of serotonin syndrome or opioid toxicity and an increased risk of CNS depression Details

Major

Hydromorphone Injection Acepromazine PROMACE Increased risk of respiratory and CNS depression Details Hydromorphone Injection Aclidinium Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Injection Alfentanil Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydromorphone Injection Almotriptan Increased risk of serotonin syndrome Details Hydromorphone Injection Alprazolam Xanax Increased risk of respiratory and CNS depression Details Hydromorphone Injection Amantadine Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Injection Amifampridine Increased risk of seizures Details Hydromorphone Injection Amiloride Reduced efficacy of diuretics Details Hydromorphone Injection Amineptine Increased risk of serotonin syndrome Details Hydromorphone Injection Amitriptyline Elavil Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Hydromorphone Injection Amitriptylinoxide Increased risk of serotonin syndrome Details Hydromorphone Injection Amobarbital Amytal Increased risk of respiratory and CNS depression Details Hydromorphone Injection Amoxapine Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Hydromorphone Injection Amphetamine Dexedrine Increased risk of serotonin syndrome Details Hydromorphone Injection Anileridine Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydromorphone Injection Aripiprazole Abilify Increased risk of respiratory and CNS depression Details Hydromorphone Injection Aripiprazole Lauroxil Aristada Increased risk of respiratory and CNS depression Details Hydromorphone Injection Asenapine Saphris Increased risk of respiratory and CNS depression Details Hydromorphone Injection Atropine Atropen Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Injection Baclofen Fleqsuvy Increased risk of profound sedation, respiratory depression, coma and death Details Hydromorphone Injection Belladonna Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Injection Bemetizide Reduced efficacy of diuretics Details Hydromorphone Injection Bendroflumethiazide Reduced efficacy of diuretics Details Hydromorphone Injection Benperidol Increased risk of respiratory and CNS depression Details Hydromorphone Injection Bentazepam Increased risk of respiratory and CNS depression Details Hydromorphone Injection Benzhydrocodone Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydromorphone Injection Benzphetamine Increased risk of serotonin syndrome Details Hydromorphone Injection Benzthiazide Reduced efficacy of diuretics Details Hydromorphone Injection Benztropine Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Injection Biperiden Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydromorphone Injection Bromazepam Increased risk of respiratory and CNS depression Details Hydromorphone Injection Bromopride Potentiation of sedative effects Details Hydromorphone Injection Brompheniramine Respa-BR Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Hydromorphone Injection Bumetanide Bumex Reduced efficacy of diuretics Details

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