Silver Sulfadiazine

Name: Silver Sulfadiazine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

2 interactions

Also sold as: Silvadene Silvadene® SSD SSD Cream® Thermazene Thermazene®

About Silver Sulfadiazine

Silver sulfadiazine, a sulfa drug, is used to prevent and treat infections of second- and third-degree burns. It kills a wide variety of bacteria. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Read the full Silver Sulfadiazine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Methotrexate Methotrexate Injection

2 Major

All (2) Major (2)

Major

Silver Sulfadiazine Methotrexate Jylamvo Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details Silver Sulfadiazine Methotrexate Injection Abitrexate® Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.