Siponimod

79 interactions 5 explained in plain English

Also sold as: Mayzent Mayzent®

About Siponimod

Siponimod is used to prevent episodes of symptoms and slow the worsening of disability in adults with relapsing-remitting forms (course of disease where symptoms flare up from time to time) of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, lo… Read the full Siponimod drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Esmolol Eribulin Injection Penbutolol Acebutolol Felbamate Arsenic Trioxide

78 Major 1 Moderate

All (79) Major (78) Moderate (1)

Major

Siponimod Foscarnet Injection Foscavir An increased risk of QT interval prolongation Details Siponimod Fostemsavir Rukobia Increased risk of torsade de pointes Details Siponimod Galantamine Razadyne An increased risk of QT interval prolongation Details Siponimod Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Siponimod Gemifloxacin Factive An increased risk of QT interval prolongation Details Siponimod Glasdegib Daurismo An increased risk of QT interval prolongation Details Siponimod Goserelin Implant Zoladex An increased risk of QT interval prolongation Details Siponimod Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Siponimod Granisetron Injection Granisol An increased risk of QT interval prolongation Details Siponimod Histrelin Implant Supprelin An increased risk of QT interval prolongation Details Siponimod Hydroxychloroquine Plaquenil An increased risk of QT interval prolongation Details Siponimod Inotuzumab Ozogamicin Injection Besponsa An increased risk of QT interval prolongation Details Siponimod Ivabradine Corlanor An increased risk of QT interval prolongation Details Siponimod Ketoconazole Topical Extina® Foam An increased risk of QT interval prolongation Details Siponimod Labetalol Normodyne® An increased risk of severe bradycardia and heart block Details Siponimod Lefamulin Xenleta Increased risk of QT interval prolongation Details Siponimod Levofloxacin Levaquin An increased risk of QT interval prolongation Details Siponimod Levofloxacin Injection Levaquin An increased risk of QT interval prolongation Details Siponimod Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Siponimod Mefloquine Lariam® An increased risk of QT interval prolongation Details Siponimod Metronidazole Flagyl An increased risk of QT interval prolongation Details Siponimod Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Siponimod Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Siponimod Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Siponimod Moxifloxacin Avelox An increased risk of QT interval prolongation Details Siponimod Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Siponimod Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Siponimod Nadolol Corgard An increased risk of severe bradycardia and heart block Details Siponimod Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation Details Siponimod Nebivolol Bystolic An increased risk of severe bradycardia and heart block Details Siponimod Octreotide Bynfezia An increased risk of QT interval prolongation Details Siponimod Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Siponimod Ofloxacin Floxin® An increased risk of QT interval prolongation Details Siponimod Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Siponimod Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Siponimod Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Siponimod Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Siponimod Penbutolol Levatol® An increased risk of severe bradycardia and heart block Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.