Siponimod

79 interactions 5 explained in plain English
Also sold as: Mayzent Mayzent®
About Siponimod

Siponimod is used to prevent episodes of symptoms and slow the worsening of disability in adults with relapsing-remitting forms (course of disease where symptoms flare up from time to time) of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, lo… Read the full Siponimod drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Esmolol Eribulin Injection Penbutolol Acebutolol Felbamate Arsenic Trioxide
78 Major 1 Moderate
All (79) Major (78) Moderate (1)

Moderate

Siponimod Mitapivat Aqvesme Reduced CYP2C9 substrate exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.