Smallpox Monkeypox Vaccine

204 interactions 5 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Carboplatin Afatinib Pentostatin Injection Lenalidomide Melphalan Injection Azacitidine

167 Contraindicated 24 Major 13 Moderate

All (204) Contraindicated (167) Major (24) Moderate (13)

Contraindicated

Smallpox Monkeypox Vaccine Relugolix Orgovyx Explained An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Abemaciclib Verzenio Explained An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Acalabrutinib Calquence An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Ado-Trastuzumab Emtansine Injection KADCYLA An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Aldesleukin Proleukin An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Alectinib Alecensa An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Alpelisib Piqray An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Amivantamab-Vmjw Injection Rybrevant An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Anastrozole Arimidex An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Arsenic Trioxide Trisenox An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Arsenic Trioxide Injection Trisenox An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Asciminib Scemblix An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Avapritinib Ayvakit An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Avelumab Injection Bavencio An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Axicabtagene Ciloleucel Injection Yescarta An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Azacitidine Onureg An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Belinostat Injection Beleodaq An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Belumosudil Rezurock Explained An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Bicalutamide Casodex An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Afatinib Gilotrif An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Asparaginase Erwinia Chrysanthemi Injection Erwinaze An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Atezolizumab Injection Tecentriq An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Axitinib Inlyta An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Azacitidine Injection Onureg An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Belantamab Mafodotin-Blmf Injection Blenrep An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Bendamustine Injection Belrapzo An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Bevacizumab Injection Alymsys An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Bexarotene Targretin An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Bexarotene Topical Targretin An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Binimetinib Mektovi An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Bleomycin Blenoxane® An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Bortezomib Boruzu An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Bosutinib Bosulif An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Brentuximab Vedotin Injection Adcetris An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Brexucabtagene Autoleucel Injection Tecartus An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Blinatumomab Injection Blincyto An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Brigatinib Alunbrig An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Busulfan Injection Busulfex An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Cabazitaxel Injection Jevtana An increased risk of infection by the live vaccine Details Smallpox Monkeypox Vaccine Cabozantinib Cabometyx An increased risk of infection by the live vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.