Sodium Polystyrene Sulfonate

Name: Sodium Polystyrene Sulfonate Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

4 interactions

Also sold as: Kalexate® Kayexalate® Kionex Kionex® SPS SPS®

About Sodium Polystyrene Sulfonate

Sodium polystyrene sulfonate is used to treat hyperkalemia (increased amounts of potassium in the body). Sodium polystyrene sulfonate is in a class of medications called potassium-removing agents. It works by removing excess potassium from the body. Read the full Sodium Polystyrene Sulfonate drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Meloxicam Meloxicam Injection

2 Major 2 Moderate

All (4) Major (2) Moderate (2)

Major

Sodium Polystyrene Sulfonate Meloxicam Alloxate Risk of intestinal necrosis Details Sodium Polystyrene Sulfonate Meloxicam Injection Alloxate Risk of intestinal necrosis Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.