Sodium Polystyrene Sulfonate

Name: Sodium Polystyrene Sulfonate Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

4 interactions

Also sold as: Kalexate® Kayexalate® Kionex Kionex® SPS SPS®

About Sodium Polystyrene Sulfonate

Sodium polystyrene sulfonate is used to treat hyperkalemia (increased amounts of potassium in the body). Sodium polystyrene sulfonate is in a class of medications called potassium-removing agents. It works by removing excess potassium from the body. Read the full Sodium Polystyrene Sulfonate drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Meloxicam Meloxicam Injection

2 Major 2 Moderate

All (4) Major (2) Moderate (2)

Major

Sodium Polystyrene Sulfonate Meloxicam Alloxate Risk of intestinal necrosis Details Sodium Polystyrene Sulfonate Meloxicam Injection Alloxate Risk of intestinal necrosis Details

Moderate

Sodium Polystyrene Sulfonate Liothyronine Cytomel Decreased liothyronine effectiveness Details Sodium Polystyrene Sulfonate Lithium Carbonate Lithobid Decreased absorption and efficacy of lithium Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.