Sofpironium

11 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amitriptyline Sertraline Trospium / Xanomeline Aclidinium Oral Inhalation Atropine Ophthalmic Cyclopentolate Ophthalmic
11 Major
All (11) Major (11)

Major

Sofpironium Amitriptyline Elavil Explained An increased risk of hyperpyrexia and heat stroke due to decreased sweating Details Sofpironium Sertraline Explained Increased CYP2D6 substrate exposure Details Sofpironium Trospium / Xanomeline Cobenfy Explained An increased risk of hyperpyrexia and heat stroke due to decreased sweating Details Sofpironium Aclidinium Oral Inhalation Tudorza An increased risk of hyperpyrexia and heat stroke due to decreased sweating Details Sofpironium Atropine Ophthalmic Atropine Care 1% An increased risk of hyperpyrexia and heat stroke due to decreased sweating Details Sofpironium Cyclopentolate Ophthalmic Akpentolate® An increased risk of hyperpyrexia and heat stroke due to decreased sweating Details Sofpironium Diphenhydramine Injection Banophen An increased risk of hyperpyrexia and heat stroke due to decreased sweating Details Sofpironium Diphenhydramine Topical Afterbite with Antihistamine An increased risk of hyperpyrexia and heat stroke due to decreased sweating Details Sofpironium Glycopyrronium Topical Cuvposa® An increased risk of hyperpyrexia and heat stroke due to decreased sweating Details Sofpironium Ipratropium Nasal Spray Atrovent Nasal Spray® An increased risk of hyperpyrexia and heat stroke due to decreased sweating Details Sofpironium Ipratropium Oral Inhalation Atrovent® HFA An increased risk of hyperpyrexia and heat stroke due to decreased sweating Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.