Sotalol

124 interactions 6 explained in plain English

Also sold as: Betapace Betapace® Betapace® AF Sorine Sorine® Sotylize

About Sotalol

Sotalol is used to treat irregular heartbeats. Sotalol is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm. Read the full Sotalol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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75 Major 49 Moderate

All (124) Major (75) Moderate (49)

Moderate

Sotalol Acarbose Prandase® Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Aspirin Acuprin® Reduced antihypertensive effect Details Sotalol Aspirin Rectal Aspirin Reduced antihypertensive effect Details Sotalol Alogliptin Nesina Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect Details Sotalol Canagliflozin Invokana Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Dapagliflozin Farxiga Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect Details Sotalol Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect Details Sotalol Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect Details Sotalol Diclofenac Transdermal Patch Flector Reduced antihypertensive effect Details Sotalol Doxazosin Cardura An exaggerated hypotensive response to the first dose of the alpha blocker Details Sotalol Dulaglutide Injection Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Ertugliflozin Steglatro Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Etodolac Lodine Reduced antihypertensive effect Details Sotalol Exenatide Injection Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Fenoprofen Fenopron Reduced antihypertensive effect Details Sotalol Flurbiprofen Ansaid Reduced antihypertensive effect Details Sotalol Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect Details Sotalol Glimepiride Amaryl Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Glipizide Glucotrol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Glucagon Injection Baqsimi A transient increase in pulse and blood pressure Details Sotalol Glucagon Injection / Solution Baqsimi A transient increase in pulse and blood pressure Details Sotalol Glucagon Nasal Powder Baqsimi A transient increase in pulse and blood pressure Details Sotalol Ibuprofen Addaprin Reduced antihypertensive effect Details Sotalol Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Insulin Detemir (Rdna Origin) Injection Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Insulin Glulisine (Rdna Origin) Injection Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Ketoprofen Actron® Reduced antihypertensive effect Details Sotalol Ketorolac Acular Reduced antihypertensive effect Details Sotalol Ketorolac Injection Acular Reduced antihypertensive effect Details Sotalol Ketorolac Nasal Spray Sprix Reduced antihypertensive effect Details Sotalol Ketorolac Ophthalmic Acular Reduced antihypertensive effect Details Sotalol Linagliptin Tradjenta Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Liraglutide Injection Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Lixisenatide Injection Adlyxin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Meclofenamate Meclodium® Reduced antihypertensive effect Details Sotalol Mefenamic Acid Ponstel® Reduced antihypertensive effect Details Sotalol Meloxicam Alloxate Reduced antihypertensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.