Sotalol

124 interactions 6 explained in plain English

Also sold as: Betapace Betapace® Betapace® AF Sorine Sorine® Sotylize

About Sotalol

Sotalol is used to treat irregular heartbeats. Sotalol is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm. Read the full Sotalol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Felbamate Sertraline Eribulin Injection Levofloxacin Injection Indacaterol Oral Inhalation Dasatinib

75 Major 49 Moderate

All (124) Major (75) Moderate (49)

Major

Sotalol Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Sertraline Explained An increased risk of QT interval prolongation Details Sotalol Albuterol Oral Inhalation Accuneb® Explained Decreased efficacy of albuterol Details Sotalol Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Sotalol Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Sotalol Acetazolamide Diamox® Sequels® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Sotalol Arsenic Trioxide Trisenox Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Sotalol Arsenic Trioxide Injection Trisenox Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Asenapine Transdermal Patch Secuado An increased risk of hypotension and an increased risk of QT interval prolongation Details Sotalol Azithromycin AzaSite An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Sotalol Alfuzosin UroXatral An increased risk of torsade de pointes Details Sotalol Anagrelide Agrylin Increased risk of QT interval prolongation Details Sotalol Bedaquiline Sirturo An increased risk of QT interval prolongation Details Sotalol Chloroquine Aralen® An increased risk of QT interval prolongation Details Sotalol Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Sotalol Dasatinib Phyrago An increased risk of QT interval prolongation Details Sotalol Degarelix Injection Firmagon An increased risk of QT interval prolongation Details Sotalol Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Sotalol Digoxin Cardoxin® Increased risk of bradycardia, advanced or complete heart block and an increased risk of proarrhythmic events Details Sotalol Disopyramide Norpace Increased risk of QT interval prolongation or prolonged refractoriness Details Sotalol Dofetilide Tikosyn Increased risk of QT interval prolongation or prolonged refractoriness Details Sotalol Dolasetron Anzemet An increased risk of QT interval prolongation Details Sotalol Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Sotalol Encorafenib Braftovi Increased risk of QT interval prolongation Details Sotalol Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Sotalol Eribulin Injection Halaven An increased risk of QT interval prolongation Details Sotalol Famotidine Calmicid An increased risk of QT interval prolongation Details Sotalol Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Sotalol Felbamate Felbatol An increased risk of QT interval prolongation Details Sotalol Flecainide Tambocor® Increased risk of QT interval prolongation or prolonged refractoriness Details Sotalol Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Fostemsavir Rukobia Increased risk of torsade de pointes Details Sotalol Furosemide Injection Disal An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Galantamine Razadyne An increased risk of QT interval prolongation Details Sotalol Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Glasdegib Daurismo Increased risk of QT interval prolongation Details Sotalol Goserelin Implant Zoladex An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.