Drug Interaction Report

Sotalol and Furosemide Injection: Interaction Details

A pharmacist-reviewed analysis of the Sotalol and Furosemide Injection interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Furosemide Injection

Disal Furoscix Furoscix® Lasix Lasix® Salix - substance
+

Sotalol

Betapace Betapace® Betapace® AF Sorine Sorine® Sotylize
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 124 documented Sotalol interactions, 75 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
probable
Severity
Major

What happens

An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest)

Interaction Deep Dive

Hypokalemia and hypomagnesemia caused by diuretics may increase the risk of sotalol toxicity. Correction of potassium and magnesium imbalance should be undertaken prior to sotalol therapy, as these conditions can exaggerate the degree of QT prolongation, and increase the potential for torsade de pointes12.

Why it happens (mechanism)

Potassium and magnesium loss secondary to diuretics

Common questions

Can I take Sotalol and Furosemide Injection together?

An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Always confirm with your pharmacist or prescriber before making any change.

How serious is the Sotalol and Furosemide Injection interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

Questions for your pharmacist

  • Does my dose of Sotalol or Furosemide Injection need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (2)

  1. Yamreudeewong W, DeBisschop M, Martin LG, et al: Potentially significant drug interactions of class III antiarrhythmic drugs. Drug Safety 2003; 26(6):421-438. PubMed
  2. Product Information: Betapace(R), sotalol HCl. Berlex Laboratories, Wayne, NJ, 2001. DailyMed
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Furosemide Injection

Keep reading about Furosemide Injection

All Furosemide Injection interactions (241) Furosemide Injection drug information
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Sotalol

Keep reading about Sotalol

All Sotalol interactions (124) Sotalol drug information
Also serious with: Eribulin Injection Sertraline Oxaliplatin Injection Dasatinib
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Sotalol + Activated Charcoal American Hellebore Arsenic Cesium Ephedra Grapefruit Indian Snakeroot Sida Cordifolia + 35 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.